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Synthesis of 1,2-trans-2-acetamido-2-deoxyhomoiminosugars.
Blériot Y, Tran AT, Prencipe G, Jagadeesh Y, Auberger N, Zhu S, Gauthier C, Zhang Y, Désiré J, Adachi I, Kato A, Sollogoub M. Blériot Y, et al. Among authors: adachi i. Org Lett. 2014 Nov 7;16(21):5516-9. doi: 10.1021/ol502929h. Epub 2014 Oct 20. Org Lett. 2014. PMID: 25330462
Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.
Cendret V, Legigan T, Mingot A, Thibaudeau S, Adachi I, Forcella M, Parenti P, Bertrand J, Becq F, Norez C, Désiré J, Kato A, Blériot Y. Cendret V, et al. Among authors: adachi i. Org Biomol Chem. 2015 Nov 21;13(43):10734-44. doi: 10.1039/c5ob01526j. Org Biomol Chem. 2015. PMID: 26356422 Free article.
N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.
Désiré J, Mondon M, Fontelle N, Nakagawa S, Hirokami Y, Adachi I, Iwaki R, Fleet GW, Alonzi DS, Twigg G, Butters TD, Bertrand J, Cendret V, Becq F, Norez C, Marrot J, Kato A, Blériot Y. Désiré J, et al. Among authors: adachi i. Org Biomol Chem. 2014 Nov 28;12(44):8977-96. doi: 10.1039/c4ob00325j. Org Biomol Chem. 2014. PMID: 25277226
Multivalency To Inhibit and Discriminate Hexosaminidases.
Alvarez-Dorta D, King DT, Legigan T, Ide D, Adachi I, Deniaud D, Désiré J, Kato A, Vocadlo D, Gouin SG, Blériot Y. Alvarez-Dorta D, et al. Among authors: adachi i. Chemistry. 2017 Jul 6;23(38):9022-9025. doi: 10.1002/chem.201701756. Epub 2017 Jun 20. Chemistry. 2017. PMID: 28548311 Free article.
Eight stereoisomers of homonojirimycin from D-mannose.
Lenagh-Snow GM, Jenkinson SF, Newberry SJ, Kato A, Nakagawa S, Adachi I, Wormald MR, Yoshihara A, Morimoto K, Akimitsu K, Izumori K, Fleet GW. Lenagh-Snow GM, et al. Among authors: adachi i. Org Lett. 2012 Apr 20;14(8):2050-3. doi: 10.1021/ol3005744. Epub 2012 Apr 3. Org Lett. 2012. PMID: 22472134
Synthesis from D-altrose of (5R,6R,7R,8S)-5,7-dihydroxy-8-hydroxymethylconidine and 2,4-dideoxy-2,4-imino-D-glucitol, azetidine analogues of swainsonine and 1,4-dideoxy-1,4-imino-D-mannitol.
Araújo N, Jenkinson SF, Martínez RF, Glawar AF, Wormald MR, Butters TD, Nakagawa S, Adachi I, Kato A, Yoshihara A, Akimitsu K, Izumori K, Fleet GW. Araújo N, et al. Among authors: adachi i. Org Lett. 2012 Aug 17;14(16):4174-7. doi: 10.1021/ol301844n. Epub 2012 Jul 27. Org Lett. 2012. PMID: 22839435
761 results