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Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9 Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer.
Venkatesan JK, Meng W, Rey-Rico A, Schmitt G, Speicher-Mentges S, Falentin-Daudré C, Leroux A, Madry H, Migonney V, Cucchiarini M. Venkatesan JK, et al. Among authors: speicher mentges s. Pharmaceutics. 2020 Mar 21;12(3):280. doi: 10.3390/pharmaceutics12030280. Pharmaceutics. 2020. PMID: 32245159 Free PMC article.
Thermosensitive Hydrogel Based on PEO-PPO-PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno-Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects.
Madry H, Gao L, Rey-Rico A, Venkatesan JK, Müller-Brandt K, Cai X, Goebel L, Schmitt G, Speicher-Mentges S, Zurakowski D, Menger MD, Laschke MW, Cucchiarini M. Madry H, et al. Adv Mater. 2020 Jan;32(2):e1906508. doi: 10.1002/adma.201906508. Epub 2019 Nov 25. Adv Mater. 2020. PMID: 31763733
rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells.
Meng W, Rey-Rico A, Claudel M, Schmitt G, Speicher-Mentges S, Pons F, Lebeau L, Venkatesan JK, Cucchiarini M. Meng W, et al. Among authors: speicher mentges s. Nanomaterials (Basel). 2020 Apr 28;10(5):855. doi: 10.3390/nano10050855. Nanomaterials (Basel). 2020. PMID: 32354138 Free PMC article.
Hydrogel-Guided, rAAV-Mediated IGF-I Overexpression Enables Long-Term Cartilage Repair and Protection against Perifocal Osteoarthritis in a Large-Animal Full-Thickness Chondral Defect Model at One Year In Vivo.
Maihöfer J, Madry H, Rey-Rico A, Venkatesan JK, Goebel L, Schmitt G, Speicher-Mentges S, Cai X, Meng W, Zurakowski D, Menger MD, Laschke MW, Cucchiarini M. Maihöfer J, et al. Among authors: speicher mentges s. Adv Mater. 2021 Apr;33(16):e2008451. doi: 10.1002/adma.202008451. Epub 2021 Mar 18. Adv Mater. 2021. PMID: 33734514
rAAV-Mediated sox9 Overexpression Improves the Repair of Osteochondral Defects in a Clinically Relevant Large Animal Model Over Time In Vivo and Reduces Perifocal Osteoarthritic Changes.
Lange C, Madry H, Venkatesan JK, Schmitt G, Speicher-Mentges S, Zurakowski D, Menger MD, Laschke MW, Cucchiarini M. Lange C, et al. Among authors: speicher mentges s. Am J Sports Med. 2021 Nov;49(13):3696-3707. doi: 10.1177/03635465211049414. Epub 2021 Oct 13. Am J Sports Med. 2021. PMID: 34643471
Axial alignment is a critical regulator of knee osteoarthritis.
Oláh T, Reinhard J, Laschke MW, Goebel LKH, Walter F, Schmitt G, Speicher-Mentges S, Menger MD, Cucchiarini M, Pape D, Madry H. Oláh T, et al. Among authors: speicher mentges s. Sci Transl Med. 2022 Jan 26;14(629):eabn0179. doi: 10.1126/scitranslmed.abn0179. Epub 2022 Jan 26. Sci Transl Med. 2022. PMID: 35080913
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