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Page 1
The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin.
Schrøder TJ, Christensen S, Lindberg S, Langgård M, David L, Maltas PJ, Eskildsen J, Jacobsen J, Tagmose L, Simonsen KB, Biilmann Rønn LC, de Jong IE, Malik IJ, Karlsson JJ, Bundgaard C, Egebjerg J, Stavenhagen JB, Strandbygård D, Thirup S, Andersen JL, Uppalanchi S, Pervaram S, Kasturi SP, Eradi P, Sakumudi DR, Watson SP. Schrøder TJ, et al. Among authors: simonsen kb. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80. doi: 10.1016/j.bmcl.2013.11.046. Epub 2013 Nov 27. Bioorg Med Chem Lett. 2014. PMID: 24355129
Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex.
Andersen JL, Schrøder TJ, Christensen S, Strandbygård D, Pallesen LT, García-Alai MM, Lindberg S, Langgård M, Eskildsen JC, David L, Tagmose L, Simonsen KB, Maltas PJ, Rønn LC, de Jong IE, Malik IJ, Egebjerg J, Karlsson JJ, Uppalanchi S, Sakumudi DR, Eradi P, Watson SP, Thirup S. Andersen JL, et al. Among authors: simonsen kb. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):451-60. doi: 10.1107/S1399004713030149. Epub 2014 Jan 29. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24531479 Free PMC article.
Identification of a new series of non-peptidic NK3 receptor antagonists.
Juhl K, Hansen T, Kehler J, Khanzhin NA, Nørgaard MB, Ruhland T, Larsen DB, Jensen KG, Steiniger-Brach B, Nielsen SM, Simonsen KB. Juhl K, et al. Among authors: simonsen kb. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1498-501. doi: 10.1016/j.bmcl.2010.12.135. Epub 2011 Jan 13. Bioorg Med Chem Lett. 2011. PMID: 21292483
Rational design of azepane-glycoside antibiotics targeting the bacterial ribosome.
Barluenga S, Simonsen KB, Littlefield ES, Ayida BK, Vourloumis D, Winters GC, Takahashi M, Shandrick S, Zhao Q, Han Q, Hermann T. Barluenga S, et al. Among authors: simonsen kb. Bioorg Med Chem Lett. 2004 Feb 9;14(3):713-8. doi: 10.1016/j.bmcl.2003.11.028. Bioorg Med Chem Lett. 2004. PMID: 14741274
Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase.
Lira R, Xiang AX, Doundoulakis T, Biller WT, Agrios KA, Simonsen KB, Webber SE, Sisson W, Aust RM, Shah AM, Showalter RE, Banh VN, Steffy KR, Appleman JR. Lira R, et al. Among authors: simonsen kb. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6797-800. doi: 10.1016/j.bmcl.2007.10.017. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 17980587
IMI European Lead Factory - democratizing access to high-throughput screening.
Jones PS, Boucharens S, McElroy SP, Morrison A, Honarnejad S, van Boeckel S, van den Hurk H, Basting D, Hüser J, Jaroch S, Ottow E, Benningshof J, Folmer RHA, Leemhuis F, Kramer-Verhulst PM, Nies VJM, Orrling KM, Rijnders T, Pfander C, Engkvist O, Pairaudeau G, Simpson PB, Ortholand JY, Roche D, Dömling A, Kühnert SM, Roevens PWM, van Vlijmen H, van Wanrooij EJA, Verbruggen C, Nussbaumer P, Ovaa H, van der Stelt M, Simonsen KB, Tagmose L, Waldmann H, Duffy J, Finsinger D, Jurzak M, Burgess-Brown NA, Lee WH, Rutjes FPJT, Haag H, Kallus C, Mors H, Dorval T, Lesur B, Ramon Olayo F, Hamza D, Jones G, Pearce C, Piechot A, Tzalis D, Clausen MH, Davis J, Derouane D, Vermeiren C, Kaiser M, Stockman RA, Barrault DV, Pannifer AD, Swedlow JR, Nelson AS, Orru RVA, Ruijter E, van Helden SP, Li VM, Vries T, de Vlieger JSB. Jones PS, et al. Among authors: simonsen kb. Nat Rev Drug Discov. 2022 Apr;21(4):245-246. doi: 10.1038/d41573-021-00196-3. Nat Rev Drug Discov. 2022. PMID: 34907316 No abstract available.
31 results