Abstract
Syntheses of dehydroalanine derivatives via a solid-support route, starting from selenocystein, and via conventional solution phase chemistry are described along with initial biological testing. The target compounds were designed as mimetics of the dehydroalanine side chain of the macrocyclic antibiotic thiostrepton that acts on the bacterial ribosome.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alanine / analogs & derivatives*
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Alanine / chemical synthesis
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Chromatography, Liquid
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Mimicry*
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Thiostrepton / chemistry*
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Thiostrepton / pharmacology
Substances
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dehydroalanine
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Thiostrepton
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Alanine