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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas.
Chung C, Sweha SR, Pratt D, Tamrazi B, Panwalkar P, Banda A, Bayliss J, Hawes D, Yang F, Lee HJ, Shan M, Cieslik M, Qin T, Werner CK, Wahl DR, Lyssiotis CA, Bian Z, Shotwell JB, Yadav VN, Koschmann C, Chinnaiyan AM, Blüml S, Judkins AR, Venneti S. Chung C, et al. Among authors: lyssiotis ca. Cancer Cell. 2020 Sep 14;38(3):334-349.e9. doi: 10.1016/j.ccell.2020.07.008. Epub 2020 Aug 13. Cancer Cell. 2020. PMID: 32795401 Free PMC article.
Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease.
Glick GD, Rossignol R, Lyssiotis CA, Wahl D, Lesch C, Sanchez B, Liu X, Hao LY, Taylor C, Hurd A, Ferrara JL, Tkachev V, Byersdorfer CA, Boros L, Opipari AW. Glick GD, et al. Among authors: lyssiotis ca. J Pharmacol Exp Ther. 2014 Nov;351(2):298-307. doi: 10.1124/jpet.114.218099. Epub 2014 Aug 14. J Pharmacol Exp Ther. 2014. PMID: 25125579 Free PMC article.
Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis.
Wahl DR, Dresser J, Wilder-Romans K, Parsels JD, Zhao SG, Davis M, Zhao L, Kachman M, Wernisch S, Burant CF, Morgan MA, Feng FY, Speers C, Lyssiotis CA, Lawrence TS. Wahl DR, et al. Among authors: lyssiotis ca. Cancer Res. 2017 Feb 15;77(4):960-970. doi: 10.1158/0008-5472.CAN-16-2008. Epub 2016 Dec 6. Cancer Res. 2017. PMID: 27923831 Free PMC article.
Menin regulates the serine biosynthetic pathway in Ewing sarcoma.
Svoboda LK, Teh SSK, Sud S, Kerk S, Zebolsky A, Treichel S, Thomas D, Halbrook CJ, Lee HJ, Kremer D, Zhang L, Klossowski S, Bankhead AR, Magnuson B, Ljungman M, Cierpicki T, Grembecka J, Lyssiotis CA, Lawlor ER. Svoboda LK, et al. Among authors: lyssiotis ca. J Pathol. 2018 Jul;245(3):324-336. doi: 10.1002/path.5085. Epub 2018 May 28. J Pathol. 2018. PMID: 29672864 Free PMC article.
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response.
Núñez FJ, Mendez FM, Kadiyala P, Alghamri MS, Savelieff MG, Garcia-Fabiani MB, Haase S, Koschmann C, Calinescu AA, Kamran N, Saxena M, Patel R, Carney S, Guo MZ, Edwards M, Ljungman M, Qin T, Sartor MA, Tagett R, Venneti S, Brosnan-Cashman J, Meeker A, Gorbunova V, Zhao L, Kremer DM, Zhang L, Lyssiotis CA, Jones L, Herting CJ, Ross JL, Hambardzumyan D, Hervey-Jumper S, Figueroa ME, Lowenstein PR, Castro MG. Núñez FJ, et al. Among authors: lyssiotis ca. Sci Transl Med. 2019 Feb 13;11(479):eaaq1427. doi: 10.1126/scitranslmed.aaq1427. Sci Transl Med. 2019. PMID: 30760578 Free PMC article.
Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.
Li M, Chiang YL, Lyssiotis CA, Teater MR, Hong JY, Shen H, Wang L, Hu J, Jing H, Chen Z, Jain N, Duy C, Mistry SJ, Cerchietti L, Cross JR, Cantley LC, Green MR, Lin H, Melnick AM. Li M, et al. Among authors: lyssiotis ca. Cancer Cell. 2019 Jun 10;35(6):916-931.e9. doi: 10.1016/j.ccell.2019.05.002. Cancer Cell. 2019. PMID: 31185214 Free PMC article.
196 results