When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade

Mengrou Shan; Costas A Lyssiotis

doi:10.1016/j.cmet.2017.11.008

When Cancer Cells Are Given Lemo[NH₃]s, They Make Lemo[NH₃]ade

Cell Metab. 2017 Dec 5;26(6):811-813. doi: 10.1016/j.cmet.2017.11.008.

Authors

Mengrou Shan¹, Costas A Lyssiotis²

Affiliations

¹ Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
² Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: clyssiot@med.umich.edu.

PMID: 29211980
DOI: 10.1016/j.cmet.2017.11.008

Abstract

In normal physiology, end-products of metabolism are excreted from the body. In tumors, these metabolic wastes accumulate due to deregulated metabolism and vascular insufficiency. Spinelli et al. (2017) show that breast cancer cells adapt to ammonia buildup by recycling it for amino acid synthesis, which can support cancer cell growth.

Publication types

Comment

MeSH terms

Ammonia*
Biomass
Breast Neoplasms*
Glutamate Dehydrogenase
Humans

Substances

Ammonia
Glutamate Dehydrogenase