Horwitz SB - Search Results

1

Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners.

Nadaradjane C, Yang CH, Rodriguez-Gabin A, Ye K, Sugasawa K, Atasoylu O, Smith AB 3rd, Horwitz SB, McDaid HM. Nadaradjane C, et al. Among authors: horwitz sb. J Nat Prod. 2018 Mar 23;81(3):607-615. doi: 10.1021/acs.jnatprod.8b00111. Epub 2018 Mar 9. J Nat Prod. 2018. PMID: 29522336 Free PMC article.

2

Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity.

Smith AB, Sugasawa K, Atasoylu O, Yang CP, Horwitz SB. Smith AB, et al. Among authors: horwitz sb. J Med Chem. 2011 Sep 22;54(18):6319-27. doi: 10.1021/jm200692n. Epub 2011 Aug 26. J Med Chem. 2011. PMID: 21870795 Free PMC article.

3

Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.

Yang CH, Wang C, Ojima I, Horwitz SB. Yang CH, et al. Among authors: horwitz sb. J Nat Prod. 2018 Mar 23;81(3):600-606. doi: 10.1021/acs.jnatprod.7b01047. Epub 2018 Mar 8. J Nat Prod. 2018. PMID: 29517223 Free PMC article.

4

Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence.

Guo B, Rodriguez-Gabin A, Prota AE, Mühlethaler T, Zhang N, Ye K, Steinmetz MO, Horwitz SB, Smith AB 3rd, McDaid HM. Guo B, et al. Among authors: horwitz sb. Mol Pharmacol. 2020 Aug;98(2):156-167. doi: 10.1124/mol.119.117457. Epub 2020 Jun 26. Mol Pharmacol. 2020. PMID: 32591477 Free PMC article.

5

Utilization of Photoaffinity Labeling to Investigate Binding of Microtubule Stabilizing Agents to P-Glycoprotein and β-Tubulin.

Huang Yang CP, Horwitz SB, McDaid HM. Huang Yang CP, et al. Among authors: horwitz sb. J Nat Prod. 2022 Mar 25;85(3):720-728. doi: 10.1021/acs.jnatprod.2c00106. Epub 2022 Mar 3. J Nat Prod. 2022. PMID: 35240035 Free PMC article. Review.

6

Structural Basis of Microtubule Stabilization by Discodermolide.

Prota AE, Bargsten K, Redondo-Horcajo M, Smith AB 3rd, Yang CH, McDaid HM, Paterson I, Horwitz SB, Fernando Díaz J, Steinmetz MO. Prota AE, et al. Among authors: horwitz sb. Chembiochem. 2017 May 18;18(10):905-909. doi: 10.1002/cbic.201600696. Epub 2017 Mar 27. Chembiochem. 2017. PMID: 28207984 Free PMC article.

7

Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing mice.

Huang GS, Lopez-Barcons L, Freeze BS, Smith AB 3rd, Goldberg GL, Horwitz SB, McDaid HM. Huang GS, et al. Among authors: horwitz sb. Clin Cancer Res. 2006 Jan 1;12(1):298-304. doi: 10.1158/1078-0432.CCR-05-0229. Clin Cancer Res. 2006. PMID: 16397055 Free PMC article.

8

Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1-dependent.

Chao SK, Lin J, Brouwer-Visser J, Smith AB 3rd, Horwitz SB, McDaid HM. Chao SK, et al. Among authors: horwitz sb. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):391-6. doi: 10.1073/pnas.1016962108. Epub 2010 Dec 20. Proc Natl Acad Sci U S A. 2011. PMID: 21173253 Free PMC article.

9

Taxol^®: The First Microtubule Stabilizing Agent.

Yang CH, Horwitz SB. Yang CH, et al. Among authors: horwitz sb. Int J Mol Sci. 2017 Aug 9;18(8):1733. doi: 10.3390/ijms18081733. Int J Mol Sci. 2017. PMID: 28792473 Free PMC article. Review.

10

Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes.

Smith AB 3rd, Rucker PV, Brouard I, Freeze BS, Xia S, Horwitz SB. Smith AB 3rd, et al. Among authors: horwitz sb. Org Lett. 2005 Nov 10;7(23):5199-202. doi: 10.1021/ol0520166. Org Lett. 2005. PMID: 16268537

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