Abstract
[structure: see text] The design, synthesis, and biological evaluation of a series of (+)-discodermolide molecular probes possessing photoaffinity and fluorescent appendages has been achieved. Stereoselective olefin cross-metathesis comprised a key tactic for construction of two of the molecular probes. Three photoaffinity probes were radiolabeled with tritium.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Alkanes* / chemical synthesis
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Alkanes* / chemistry
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Benzophenones / chemistry
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Carbamates* / chemical synthesis
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Carbamates* / chemistry
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Fluorescent Dyes* / chemical synthesis
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Fluorescent Dyes* / chemistry
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Lactones* / chemical synthesis
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Lactones* / chemistry
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Molecular Probes* / chemical synthesis
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Molecular Probes* / chemistry
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Molecular Structure
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Photoaffinity Labels* / chemical synthesis
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Photoaffinity Labels* / chemistry
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Pyrones* / chemical synthesis
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Pyrones* / chemistry
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Stereoisomerism
Substances
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Alkanes
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Benzophenones
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Carbamates
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Fluorescent Dyes
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Lactones
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Molecular Probes
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Photoaffinity Labels
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Pyrones
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discodermolide