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Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone.
Zhu L, Ostash B, Rix U, Nur-E-Alam M, Mayers A, Luzhetskyy A, Mendez C, Salas JA, Bechthold A, Fedorenko V, Rohr J. Zhu L, et al. J Org Chem. 2005 Jan 21;70(2):631-8. doi: 10.1021/jo0483623. J Org Chem. 2005. PMID: 15651811 Free PMC article.
Combinatorial biosynthesis of antitumor indolocarbazole compounds.
Sánchez C, Zhu L, Braña AF, Salas AP, Rohr J, Méndez C, Salas JA. Sánchez C, et al. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):461-6. doi: 10.1073/pnas.0407809102. Epub 2004 Dec 29. Proc Natl Acad Sci U S A. 2005. PMID: 15625109 Free PMC article.
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