Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

Chem Commun (Camb). 2005 Mar 28:(12):1604-6. doi: 10.1039/b417815g. Epub 2005 Jan 27.

Abstract

L- and D-stereoisomers of amicetose were generated by combining sugar biosynthesis genes from four different antibiotic gene clusters and both sugars were transferred to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cloning, Molecular
  • Enzymes / genetics
  • Hexoses / biosynthesis*
  • Hexoses / genetics*
  • Molecular Structure
  • Naphthacenes / chemistry*
  • Naphthacenes / classification
  • Naphthacenes / pharmacology
  • Plasmids / genetics
  • Plasmids / metabolism
  • Stereoisomerism

Substances

  • Enzymes
  • Hexoses
  • Naphthacenes
  • 5838 DNI
  • amicetose