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Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms.
Andersen JB, Hultqvist LD, Jansen CU, Jakobsen TH, Nilsson M, Rybtke M, Uhd J, Fritz BG, Seifert R, Berthelsen J, Nielsen TE, Qvortrup K, Givskov M, Tolker-Nielsen T. Andersen JB, et al. Among authors: hultqvist ld. NPJ Biofilms Microbiomes. 2021 Jul 9;7(1):59. doi: 10.1038/s41522-021-00225-4. NPJ Biofilms Microbiomes. 2021. PMID: 34244523 Free PMC article.
Imaging N-Acyl Homoserine Lactone Quorum Sensing In Vivo.
Hultqvist LD, Alhede M, Jakobsen TH, Givskov M, Bjarnsholt T. Hultqvist LD, et al. Methods Mol Biol. 2018;1673:203-212. doi: 10.1007/978-1-4939-7309-5_16. Methods Mol Biol. 2018. PMID: 29130175
CDy14: a novel biofilm probe targeting exopolysaccharide Psl.
Kwon HY , Kim JY , Lee JY , Yam JKH , Hultqvist LD , Xu W , Rybtke M , Tolker-Nielsen T , Kim JJ , Kang NY , Yang L , Park SJ , Givskov M , Chang YT . Kwon HY , et al. Among authors: hultqvist ld. Chem Commun (Camb). 2018 Oct 18;54(84):11865-11868. doi: 10.1039/c8cc05544k. Chem Commun (Camb). 2018. PMID: 30204158
High efficacy treatment of murine Pseudomonas aeruginosa catheter-associated urinary tract infections using the c-di-GMP modulating anti-biofilm compound Disperazol in combination with ciprofloxacin.
Hultqvist LD, Andersen JB, Nilsson CM, Jansen CU, Rybtke M, Jakobsen TH, Nielsen TE, Qvortrup K, Moser C, Graz M, Qvortrup K, Tolker-Nielsen T, Givskov M. Hultqvist LD, et al. Antimicrob Agents Chemother. 2024 May 8:e0148123. doi: 10.1128/aac.01481-23. Online ahead of print. Antimicrob Agents Chemother. 2024. PMID: 38717093