Abstract
Detection of biofilm bacteria would be an ideal method for the physicians to diagnose chronic bacterial infections directly, but there are few imaging probes available so far. Here, we report the development of a novel biofilm detecting fluorescent probe, CDy14, through an unbiased screening of a fluorescence library and elucidated its binding partner Psl, an exopolysaccharide of the biofilm.
MeSH terms
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Biofilms*
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Boron Compounds / chemistry*
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Fluorescent Dyes / chemistry
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Fluorescent Dyes / metabolism*
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Heterocyclic Compounds, 3-Ring / chemistry*
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Microscopy, Fluorescence
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Polysaccharides, Bacterial / chemistry
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Polysaccharides, Bacterial / metabolism*
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Pseudomonas aeruginosa / chemistry
Substances
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Boron Compounds
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CDy14 compound
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Fluorescent Dyes
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Heterocyclic Compounds, 3-Ring
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Polysaccharides, Bacterial