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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1914 1
1919 1
1926 2
1931 2
1936 1
1945 1
1952 1
1955 1
1957 2
1958 1
1960 1
1962 2
1963 1
1964 6
1965 3
1966 2
1967 2
1968 9
1969 4
1970 7
1971 9
1972 17
1973 11
1974 14
1975 69
1976 70
1977 76
1978 80
1979 81
1980 142
1981 130
1982 160
1983 200
1984 213
1985 245
1986 237
1987 248
1988 243
1989 305
1990 302
1991 369
1992 397
1993 483
1994 607
1995 762
1996 940
1997 1066
1998 1241
1999 1399
2000 1560
2001 1639
2002 1785
2003 1867
2004 1959
2005 2077
2006 2228
2007 2359
2008 2446
2009 2458
2010 2616
2011 2695
2012 2707
2013 2663
2014 2723
2015 2715
2016 2531
2017 2489
2018 2508
2019 2453
2020 2487
2021 2512
2022 2124
2023 2188
2024 1035

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61,213 results

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Page 1
The development and improvement of immunodeficient mice and humanized immune system mouse models.
Chen J, Liao S, Xiao Z, Pan Q, Wang X, Shen K, Wang S, Yang L, Guo F, Liu HF, Pan Q. Chen J, et al. Front Immunol. 2022 Oct 19;13:1007579. doi: 10.3389/fimmu.2022.1007579. eCollection 2022. Front Immunol. 2022. PMID: 36341323 Free PMC article. Review.
However, animal models of different diseases do not fully mimic the complex internal environment of humans. Immunodeficient mice are deficient in certain genes and do not express these or show reduced expression in some of their cells, facilitating the establishment of hum …
However, animal models of different diseases do not fully mimic the complex internal environment of humans. Immunodeficient mice are …
Factor D.
Sekine H, Machida T, Fujita T. Sekine H, et al. Immunol Rev. 2023 Jan;313(1):15-24. doi: 10.1111/imr.13155. Epub 2022 Oct 31. Immunol Rev. 2023. PMID: 36316810 Review.
Recently, a serendipitous discovery in the mechanism of FD activation has been provided by a generation of Masp1 gene knockout mice lacking both the serine protease MASP-1 and its alternative splicing variant MASP-3, designated MASP-1/3-deficient mice. ...Her …
Recently, a serendipitous discovery in the mechanism of FD activation has been provided by a generation of Masp1 gene knockout mice …
Establishment of Nude Mice Lacking NK Cells and Their Application for Human Tumor Xenografts.
Panaampon J, Sasamoto K, Kariya R, Okada S. Panaampon J, et al. Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1069-1074. doi: 10.31557/APJCP.2021.22.4.1069. Asian Pac J Cancer Prev. 2021. PMID: 33906298 Free PMC article.
METHODS: BALB/c Nude Jak3-/- (Nude-J) mice were established by crossing BALB/c Nude mice and BALB/c Jak-3-/- mice. Hematopoietic malignant cell lines (BCBL-1 and Z138) were implanted subcutaneously to compare the tumorigenicity in Nude-J mice with Nude …
METHODS: BALB/c Nude Jak3-/- (Nude-J) mice were established by crossing BALB/c Nude mice and BALB/c Jak-3-/- mice. Hema …
Urinary protein analysis in mice lacking major urinary proteins.
Suzuki O, Koura M, Uchio-Yamada K, Sasaki M. Suzuki O, et al. Exp Anim. 2021 Aug 6;70(3):406-411. doi: 10.1538/expanim.21-0010. Epub 2021 Apr 20. Exp Anim. 2021. PMID: 33883349 Free PMC article.
To resolve these problems, we produced MUP-knockout (Mup-KO) mice by removing the Mup gene cluster using Cas9 proteins and two guide RNAs and characterized the urinary proteins in these mice. ...The urinary protein concentration was significantly lower (P<0.001) …
To resolve these problems, we produced MUP-knockout (Mup-KO) mice by removing the Mup gene cluster using Cas9 proteins and two guide …
Mice lacking all of the Skint family genes.
Narita T, Nitta T, Nitta S, Okamura T, Takayanagi H. Narita T, et al. Int Immunol. 2018 Jun 26;30(7):301-309. doi: 10.1093/intimm/dxy030. Int Immunol. 2018. PMID: 29718261
The Skint family in mouse consists of 11 members, Skint1-11. Here we generated mutant mice lacking the entire genomic region that contains all of the Skint genes. These mice exhibited a marked reduction of Vgamma5Vdelta1 gammadeltaT cells in the thymus and sk …
The Skint family in mouse consists of 11 members, Skint1-11. Here we generated mutant mice lacking the entire genomic region t …
Mice lacking alpha-, beta1- and beta2-syntrophins exhibit diminished function and reduced dystrophin expression in both cardiac and skeletal muscle.
Kim MJ, Whitehead NP, Bible KL, Adams ME, Froehner SC. Kim MJ, et al. Hum Mol Genet. 2019 Feb 1;28(3):386-395. doi: 10.1093/hmg/ddy341. Hum Mol Genet. 2019. PMID: 30256963 Free PMC article.
Syntrophins are a family of modular adaptor proteins that are part of the dystrophin protein complex, where they recruit and anchor a variety of signaling proteins. Previously we generated mice lacking alpha- and/or beta2-syntrophin but showed that in the absence of …
Syntrophins are a family of modular adaptor proteins that are part of the dystrophin protein complex, where they recruit and anchor a variet …
Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis.
Li P, Fleischhauer L, Nicolae C, Prein C, Farkas Z, Saller MM, Prall WC, Wagener R, Heilig J, Niehoff A, Clausen-Schaumann H, Alberton P, Aszodi A. Li P, et al. Int J Mol Sci. 2020 Jan 19;21(2):666. doi: 10.3390/ijms21020666. Int J Mol Sci. 2020. PMID: 31963938 Free PMC article.
Matn1-4(-/-) mice were viable and fertile, and showed a lumbosacral transition phenotype characterized by the sacralization of the sixth lumbar vertebra. The development of the appendicular skeleton, the structure of the growth plate, chondrocyte differentiation, prolifera …
Matn1-4(-/-) mice were viable and fertile, and showed a lumbosacral transition phenotype characterized by the sacralization of the si …
IL-6 in the infarcted heart is preferentially formed by fibroblasts and modulated by purinergic signaling.
Alter C, Henseler AS, Owenier C, Hesse J, Ding Z, Lautwein T, Bahr J, Hayat S, Kramann R, Kostenis E, Scheller J, Schrader J. Alter C, et al. J Clin Invest. 2023 Jun 1;133(11):e163799. doi: 10.1172/JCI163799. J Clin Invest. 2023. PMID: 36943408 Free PMC article.
CFs highly expressed Adora2b and rapidly degraded extracellular ATP to AMP but lacked CD73. In mice and humans, scRNA-Seq revealed that Adora2B was also mainly expressed by fibroblasts. We assessed global IL-6 production in isolated hearts from mice lackin …
CFs highly expressed Adora2b and rapidly degraded extracellular ATP to AMP but lacked CD73. In mice and humans, scRNA-Seq reve …
NOD-scid IL2rgammanull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.
Aryee KE, Shultz LD, Burzenski LM, Greiner DL, Brehm MA. Aryee KE, et al. J Leukoc Biol. 2023 May 2;113(5):418-433. doi: 10.1093/jleuko/qiac020. J Leukoc Biol. 2023. PMID: 36801998
The inflammation induced by agents such as Toll-like receptor agonists is thought to stimulate tumor-specific immunity in patients and augment control of tumor burden. While NOD-scid IL2rgammanull mice lack murine adaptive immunity (T cells and B cells), these mice …
The inflammation induced by agents such as Toll-like receptor agonists is thought to stimulate tumor-specific immunity in patients and augme …
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