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Page 1
Mice lacking Bmp6 function.
Solloway MJ, Dudley AT, Bikoff EK, Lyons KM, Hogan BL, Robertson EJ. Solloway MJ, et al. Dev Genet. 1998;22(4):321-39. doi: 10.1002/(SICI)1520-6408(1998)22:4<321::AID-DVG3>3.0.CO;2-8. Dev Genet. 1998. PMID: 9664685
The resulting Bmp6 mutant mice are viable and fertile, and show no overt defects in tissues known to express Bmp6 mRNA. ...In situ hybridization studies in the developing long bones and sternum show that other BMP family members are expressed in overlapping d …
The resulting Bmp6 mutant mice are viable and fertile, and show no overt defects in tissues known to express Bmp6 mRNA. …
BMP5 contributes to hepcidin regulation and systemic iron homeostasis in mice.
Xiao X, Xu Y, Moschetta GA, Yu Y, Fisher AL, Alfaro-Magallanes VM, McMillen S, Phillips S, Wang CY, Christian J, Babitt JL. Xiao X, et al. Blood. 2023 Oct 12;142(15):1312-1322. doi: 10.1182/blood.2022019195. Blood. 2023. PMID: 37478395
The bone morphogenetic protein (BMP) signaling pathway is a critical regulator of hepcidin expression in response to iron and erythropoietic drive. Although endothelial-derived BMP6 and BMP2 ligands have key functional roles as endogenous hepcidin regulators, both i …
The bone morphogenetic protein (BMP) signaling pathway is a critical regulator of hepcidin expression in response to iron and erythropoietic …
Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice.
Pauk M, Grgurevic L, Brkljacic J, Kufner V, Bordukalo-Niksic T, Grabusic K, Razdorov G, Rogic D, Zuvic M, Oppermann H, Babitt JL, Lin HY, Volarevic S, Vukicevic S. Pauk M, et al. Int Orthop. 2015 Jan;39(1):161-72. doi: 10.1007/s00264-014-2550-4. Epub 2014 Oct 11. Int Orthop. 2015. PMID: 25300398
PURPOSE: Iron overload accelerates bone loss in mice lacking the bone morphogenetic protein 6 (Bmp6) gene, which is the key endogenous regulator of hepcidin, iron homeostasis gene. ...In parallel, we provided the first evidence that BMP6 circulates in …
PURPOSE: Iron overload accelerates bone loss in mice lacking the bone morphogenetic protein 6 (Bmp6) gene, which is the …
Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin.
Latour C, Besson-Fournier C, Meynard D, Silvestri L, Gourbeyre O, Aguilar-Martinez P, Schmidt PJ, Fleming MD, Roth MP, Coppin H. Latour C, et al. Hepatology. 2016 Jan;63(1):126-37. doi: 10.1002/hep.28254. Epub 2015 Nov 12. Hepatology. 2016. PMID: 26406355
To answer this question, we produced double knockout mice for Bmp6 and beta2-microglobulin (a surrogate for the loss of Hfe) and for Bmp6 and Tfr2, and we compared their phenotype (hepcidin expression, Bmp/Smad signaling, hepatic and extrahepatic tissue iron …
To answer this question, we produced double knockout mice for Bmp6 and beta2-microglobulin (a surrogate for the loss of Hfe) a …
Matriptase-2 and Hemojuvelin in Hepcidin Regulation: In Vivo Immunoblot Studies in Mask Mice.
Krijt J, Frýdlová J, Gurieva I, Přikryl P, Báječný M, Steinbicker AU, Vokurka M, Truksa J. Krijt J, et al. Int J Mol Sci. 2021 Mar 6;22(5):2650. doi: 10.3390/ijms22052650. Int J Mol Sci. 2021. PMID: 33800732 Free PMC article.
The purpose of the study was to investigate the interaction of matriptase-2 with hemojuvelin protein in vivo. Mice lacking the matriptase-2 proteolytic activity (mask mice) display decreased content of hemojuvelin protein. ...Treatment of iron-overloaded mask …
The purpose of the study was to investigate the interaction of matriptase-2 with hemojuvelin protein in vivo. Mice lacking the …
Agmatine modulates melanogenesis via MITF signaling pathway.
Kwon EJ, Kim MM. Kwon EJ, et al. Environ Toxicol Pharmacol. 2017 Jan;49:124-130. doi: 10.1016/j.etap.2016.12.008. Epub 2016 Dec 13. Environ Toxicol Pharmacol. 2017. PMID: 27988355
However, the research of agmatine on melanin synthesis related to hair greying is lacking. The aim of this study was to investigate the melanogenic effect of agmatine via regulation of MITF signaling pathway in B16F1 cells. ...
However, the research of agmatine on melanin synthesis related to hair greying is lacking. The aim of this study was to investigate t …
Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.
Roetto A, Di Cunto F, Pellegrino RM, Hirsch E, Azzolino O, Bondi A, Defilippi I, Carturan S, Miniscalco B, Riondato F, Cilloni D, Silengo L, Altruda F, Camaschella C, Saglio G. Roetto A, et al. Blood. 2010 Apr 22;115(16):3382-9. doi: 10.1182/blood-2009-09-240960. Epub 2010 Feb 23. Blood. 2010. PMID: 20179178 Free article.
Adult Tfr2 KO mice show liver iron overload and inadequate hepcidin levels relative to body iron stores, even though they increase Bmp6 production. KI mice have normal transferrin saturation, liver iron concentration, hepcidin and Bmp6 levels but show …
Adult Tfr2 KO mice show liver iron overload and inadequate hepcidin levels relative to body iron stores, even though they increase …
BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism.
Mayeur C, Leyton PA, Kolodziej SA, Yu B, Bloch KD. Mayeur C, et al. Blood. 2014 Sep 25;124(13):2116-23. doi: 10.1182/blood-2014-04-572644. Epub 2014 Jul 29. Blood. 2014. PMID: 25075125 Free PMC article.
We sought to identify which BMP type II receptor expressed in hepatocytes, ActR2a or BMPR2, is responsible for regulating hepcidin gene expression. We studied Bmpr2 heterozygous mice (Bmpr2(+/-)), mice with hepatocyte-specific deficiency of BMPR2, mice with g …
We sought to identify which BMP type II receptor expressed in hepatocytes, ActR2a or BMPR2, is responsible for regulating hepcidin gene expr …
Maturational disturbance of chondrocytes in Cbfa1-deficient mice.
Inada M, Yasui T, Nomura S, Miyake S, Deguchi K, Himeno M, Sato M, Yamagiwa H, Kimura T, Yasui N, Ochi T, Endo N, Kitamura Y, Kishimoto T, Komori T. Inada M, et al. Dev Dyn. 1999 Apr;214(4):279-90. doi: 10.1002/(SICI)1097-0177(199904)214:4<279::AID-AJA1>3.0.CO;2-W. Dev Dyn. 1999. PMID: 10213384 Free article.
Cbfa1, a transcription factor that belongs to the runt-domain gene family, plays an essential role in osteogenesis. Cbfa1-deficient mice completely lacked both intramembranous and endochondral ossification, owing to the maturational arrest of osteoblasts, indicating …
Cbfa1, a transcription factor that belongs to the runt-domain gene family, plays an essential role in osteogenesis. Cbfa1-deficient mice …
Expression profiling of ovarian BMP antagonists reveals the potential interaction between TWSG1 and the chordin subfamily in the ovary.
Wang YW, Wu CH, Lin TY, Luo CW. Wang YW, et al. Mol Cell Endocrinol. 2021 Dec 1;538:111457. doi: 10.1016/j.mce.2021.111457. Epub 2021 Sep 11. Mol Cell Endocrinol. 2021. PMID: 34517078
In contrast to a plethora of studies on the ovary-expressed TGF-beta superfamily members, knowledge regarding their antagonists, including their expression profiles and antagonism preferences, is still lacking. Using quantitative PCR in rats and transcriptomic dataset comp …
In contrast to a plethora of studies on the ovary-expressed TGF-beta superfamily members, knowledge regarding their antagonists, including t …
14 results