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Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.
Frolova LV, Magedov IV, Romero AE, Karki M, Otero I, Hayden K, Evdokimov NM, Banuls LM, Rastogi SK, Smith WR, Lu SL, Kiss R, Shuster CB, Hamel E, Betancourt T, Rogelj S, Kornienko A. Frolova LV, et al. Among authors: rogelj s. J Med Chem. 2013 Sep 12;56(17):6886-900. doi: 10.1021/jm400711t. Epub 2013 Aug 23. J Med Chem. 2013. PMID: 23927793 Free PMC article.
Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria.
Edwards L, Turner D, Champion C, Khandelwal M, Zingler K, Stone C, Rajapaksha RD, Yang J, Ranasinghe MI, Kornienko A, Frolova LV, Rogelj S. Edwards L, et al. Among authors: rogelj s. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1879-1886. doi: 10.1016/j.bmcl.2018.04.001. Epub 2018 Apr 3. Bioorg Med Chem Lett. 2018. PMID: 29673980 Free PMC article.
Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.
Magedov IV, Frolova L, Manpadi M, Bhoga Ud, Tang H, Evdokimov NM, George O, Georgiou KH, Renner S, Getlik M, Kinnibrugh TL, Fernandes MA, Van slambrouck S, Steelant WF, Shuster CB, Rogelj S, van Otterlo WA, Kornienko A. Magedov IV, et al. Among authors: rogelj s. J Med Chem. 2011 Jun 23;54(12):4234-46. doi: 10.1021/jm200410r. Epub 2011 May 26. J Med Chem. 2011. PMID: 21615090 Free PMC article.
Reengineered epipodophyllotoxin.
Magedov IV, Evdokimov NM, Karki M, Peretti AS, Lima DT, Frolova LV, Reisenauer MR, Romero AE, Tongwa P, Fonari A, Altig J, Rogelj S, Antipin MY, Shuster CB, Kornienko A. Magedov IV, et al. Among authors: rogelj s. Chem Commun (Camb). 2012 Oct 28;48(84):10416-8. doi: 10.1039/c2cc35044k. Epub 2012 Sep 17. Chem Commun (Camb). 2012. PMID: 22986348 Free PMC article.
Synthetic and biological studies of tubulin targeting c2-substituted 7-deazahypoxanthines derived from marine alkaloid rigidins.
Scott R, Karki M, Reisenauer MR, Rodrigues R, Dasari R, Smith WR, Pelly SC, van Otterlo WAL, Shuster CB, Rogelj S, Magedov IV, Frolova LV, Kornienko A. Scott R, et al. Among authors: rogelj s. ChemMedChem. 2014 Jul;9(7):1428-1435. doi: 10.1002/cmdc.201300532. Epub 2014 Mar 18. ChemMedChem. 2014. PMID: 24644272 Free PMC article.
Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines.
Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Kälin RE, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. Dasari R, et al. Among authors: rogelj s. Eur J Med Chem. 2015 Oct 20;103:226-37. doi: 10.1016/j.ejmech.2015.08.047. Epub 2015 Aug 29. Eur J Med Chem. 2015. PMID: 26360047 Free PMC article.
Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities.
Medellin DC, Zhou Q, Scott R, Hill RM, Frail SK, Dasari R, Ontiveros SJ, Pelly SC, van Otterlo WA, Betancourt T, Shuster CB, Hamel E, Bai R, LaBarbera DV, Rogelj S, Frolova LV, Kornienko A. Medellin DC, et al. Among authors: rogelj s. J Med Chem. 2016 Jan 14;59(1):480-5. doi: 10.1021/acs.jmedchem.5b01426. Epub 2015 Dec 17. J Med Chem. 2016. PMID: 26641132 Free PMC article.
70 results