Abstract
A novel reaction of indole with aryldiazonium salts leading to the formation of 2-aryl-3-(arylazo)indoles was discovered. The products were found to possess potent anti-MRSA and anti-LLVRE activities. The SAR studies indicate that the potentially metabolically labile azo functionality can be replaced with ether oxygen and thioether sulfur atoms without any loss of activity.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Bacteria / drug effects*
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Diazonium Compounds / chemistry*
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Fungi / drug effects*
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Indoles / chemical synthesis
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Indoles / chemistry
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Indoles / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Salts / chemistry
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Diazonium Compounds
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Indoles
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Salts