Abstract
A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemical synthesis
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apoptosis / drug effects
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Cell Proliferation / drug effects
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Jurkat Cells
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MCF-7 Cells
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Models, Molecular
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Molecular Structure
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Podophyllotoxin / chemical synthesis
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Podophyllotoxin / chemistry
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Podophyllotoxin / pharmacology*
Substances
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Antineoplastic Agents, Phytogenic
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Podophyllotoxin