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Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.
Frolova LV, Magedov IV, Romero AE, Karki M, Otero I, Hayden K, Evdokimov NM, Banuls LM, Rastogi SK, Smith WR, Lu SL, Kiss R, Shuster CB, Hamel E, Betancourt T, Rogelj S, Kornienko A. Frolova LV, et al. J Med Chem. 2013 Sep 12;56(17):6886-900. doi: 10.1021/jm400711t. Epub 2013 Aug 23. J Med Chem. 2013. PMID: 23927793 Free PMC article.
Reengineered epipodophyllotoxin.
Magedov IV, Evdokimov NM, Karki M, Peretti AS, Lima DT, Frolova LV, Reisenauer MR, Romero AE, Tongwa P, Fonari A, Altig J, Rogelj S, Antipin MY, Shuster CB, Kornienko A. Magedov IV, et al. Chem Commun (Camb). 2012 Oct 28;48(84):10416-8. doi: 10.1039/c2cc35044k. Epub 2012 Sep 17. Chem Commun (Camb). 2012. PMID: 22986348 Free PMC article.
Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-pyrano-[2,3-b]naphthoquinones with anticancer activity.
Magedov IV, Kireev AS, Jenkins AR, Evdokimov NM, Lima DT, Tongwa P, Altig J, Steelant WF, Van slambrouck S, Antipin MY, Kornienko A. Magedov IV, et al. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5195-8. doi: 10.1016/j.bmcl.2012.06.073. Epub 2012 Jul 4. Bioorg Med Chem Lett. 2012. PMID: 22819765 Free PMC article.
Bulbispermine: a crinine-type Amaryllidaceae alkaloid exhibiting cytostatic activity toward apoptosis-resistant glioma cells.
Luchetti G, Johnston R, Mathieu V, Lefranc F, Hayden K, Andolfi A, Lamoral-Theys D, Reisenauer MR, Champion C, Pelly SC, van Otterlo WA, Magedov IV, Kiss R, Evidente A, Rogelj S, Kornienko A. Luchetti G, et al. ChemMedChem. 2012 May;7(5):815-22. doi: 10.1002/cmdc.201100608. Epub 2012 Mar 2. ChemMedChem. 2012. PMID: 22389235 Free PMC article.
Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.
Magedov IV, Frolova L, Manpadi M, Bhoga Ud, Tang H, Evdokimov NM, George O, Georgiou KH, Renner S, Getlik M, Kinnibrugh TL, Fernandes MA, Van slambrouck S, Steelant WF, Shuster CB, Rogelj S, van Otterlo WA, Kornienko A. Magedov IV, et al. J Med Chem. 2011 Jun 23;54(12):4234-46. doi: 10.1021/jm200410r. Epub 2011 May 26. J Med Chem. 2011. PMID: 21615090 Free PMC article.
15 results