Legac J - Search Results

1

Identification, Characterization, and Synthesis of Natural Parasitic Cysteine Protease Inhibitors: Pentacitidins Are More Potent Falcitidin Analogues.

Brinkmann S, Semmler S, Kersten C, Patras MA, Kurz M, Fuchs N, Hammerschmidt SJ, Legac J, Hammann PE, Vilcinskas A, Rosenthal PJ, Schirmeister T, Bauer A, Schäberle TF. Brinkmann S, et al. Among authors: legac j. ACS Chem Biol. 2022 Mar 18;17(3):576-589. doi: 10.1021/acschembio.1c00861. Epub 2022 Mar 9. ACS Chem Biol. 2022. PMID: 35262340

2

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.

Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ, Dong C, Schupp PG, Gut J, Legac J, Cooper RA, Gamo FJ, DeRisi J, Freund YR, Fidock DA, Rosenthal PJ. Sonoiki E, et al. Among authors: legac j. Nat Commun. 2017 Mar 6;8:14574. doi: 10.1038/ncomms14574. Nat Commun. 2017. PMID: 28262680 Free PMC article.

3

Substituted 1,3-dioxoisoindoline-4-aminoquinolines coupled via amide linkers: Synthesis, antiplasmodial and cytotoxic evaluation.

Rani A, Legac J, Rosenthal PJ, Kumar V. Rani A, et al. Among authors: legac j. Bioorg Chem. 2019 Jul;88:102912. doi: 10.1016/j.bioorg.2019.04.006. Epub 2019 Apr 11. Bioorg Chem. 2019. PMID: 30991190

4

Synthesis, anti-plasmodial and cytotoxic evaluation of 1H-1,2,3-triazole/acyl hydrazide integrated tetrahydro-β-carboline-4-aminoquinoline conjugates.

Sharma B, Kaur S, Legac J, Rosenthal PJ, Kumar V. Sharma B, et al. Among authors: legac j. Bioorg Med Chem Lett. 2020 Jan 15;30(2):126810. doi: 10.1016/j.bmcl.2019.126810. Epub 2019 Nov 11. Bioorg Med Chem Lett. 2020. PMID: 31740250

5

Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials.

Rani A, Kumar S, Legac J, Adeniyi AA, Awolade P, Singh P, Rosenthal PJ, Kumar V. Rani A, et al. Among authors: legac j. Future Med Chem. 2020 Feb;12(3):193-205. doi: 10.4155/fmc-2019-0260. Epub 2019 Dec 5. Future Med Chem. 2020. PMID: 31802710 Free PMC article.

6

Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation.

Sindhe KMV, Wu W, Legac J, Zhang YK, Easom EE, Cooper RA, Plattner JJ, Freund YR, DeRisi JL, Rosenthal PJ. Sindhe KMV, et al. Among authors: legac j. mBio. 2020 Jan 28;11(1):e02640-19. doi: 10.1128/mBio.02640-19. mBio. 2020. PMID: 31992618 Free PMC article.

7

Functionalized Naphthalimide-4-aminoquinoline Conjugates as Promising Antiplasmodials, with Mechanistic Insights.

Shalini, Legac J, Adeniyi AA, Kisten P, Rosenthal PJ, Singh P, Kumar V. Shalini, et al. Among authors: legac j. ACS Med Chem Lett. 2020 Jan 8;11(2):154-161. doi: 10.1021/acsmedchemlett.9b00521. eCollection 2020 Feb 13. ACS Med Chem Lett. 2020. PMID: 32071682 Free PMC article.

8

Amalgamating Isatin/Indole/Nitroimidazole with 7-chloroquinolines via azide-alkyne cycloaddition: Synthesis, anti-plasmodial, and cytotoxic evaluation.

Kumar S, Saini A, Legac J, Rosenthal PJ, Raj R, Kumar V. Kumar S, et al. Among authors: legac j. Chem Biol Drug Des. 2020 Dec;96(6):1355-1361. doi: 10.1111/cbdd.13738. Epub 2020 Jun 25. Chem Biol Drug Des. 2020. PMID: 32515142

9

A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies.

Rani A, Sharma A, Legac J, Rosenthal PJ, Singh P, Kumar V. Rani A, et al. Among authors: legac j. Bioorg Med Chem. 2021 Jun 1;39:116159. doi: 10.1016/j.bmc.2021.116159. Epub 2021 Apr 18. Bioorg Med Chem. 2021. PMID: 33895706

10

Design, synthesis, crystal structure and anti-plasmodial evaluation of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives.

Pal K, Raza MK, Legac J, Ataur Rahman M, Manzoor S, Rosenthal PJ, Hoda N. Pal K, et al. Among authors: legac j. RSC Med Chem. 2021 May 18;12(6):970-981. doi: 10.1039/d1md00038a. eCollection 2021 Jun 23. RSC Med Chem. 2021. PMID: 34223162 Free PMC article.

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