A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies

Bioorg Med Chem. 2021 Jun 1:39:116159. doi: 10.1016/j.bmc.2021.116159. Epub 2021 Apr 18.

Abstract

Quinoline-isoniazid-phthalimide triads have been synthesised to assess their antiplasmodial efficacy and cytotoxicity against chloroquine-resistant W2 strain of P. falciparum and Vero cells, respectively. Most of the synthesized compounds displayed IC50 in lower nM range and appeared to be approximately five to twelve fold more active than chloroquine. Heme-binding studies were also carried out to delineate the mode of action. The promising compounds with IC50s in range of 11-30 nM and selectivity index >2800, may act as promising template for the design of new antiplasmodials.

Keywords: Antiplasmodial; Cytotoxicity; Heme-binding studies; Quinoline-isoniazid-phthalimide triads.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / chemical synthesis
  • Antimalarials / chemistry*
  • Antimalarials / pharmacology*
  • Chlorocebus aethiops
  • Heme / chemistry*
  • In Vitro Techniques
  • Isoniazid / chemistry*
  • Phthalimides / chemistry*
  • Plasmodium falciparum / drug effects*
  • Polymerization / drug effects*
  • Quinolines / chemistry*
  • Structure-Activity Relationship
  • Vero Cells

Substances

  • Antimalarials
  • Phthalimides
  • Quinolines
  • Heme
  • Isoniazid