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Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.
Magedov IV, Frolova L, Manpadi M, Bhoga Ud, Tang H, Evdokimov NM, George O, Georgiou KH, Renner S, Getlik M, Kinnibrugh TL, Fernandes MA, Van slambrouck S, Steelant WF, Shuster CB, Rogelj S, van Otterlo WA, Kornienko A. Magedov IV, et al. J Med Chem. 2011 Jun 23;54(12):4234-46. doi: 10.1021/jm200410r. Epub 2011 May 26. J Med Chem. 2011. PMID: 21615090 Free PMC article.
In search of a cytostatic agent derived from the alkaloid lycorine: synthesis and growth inhibitory properties of lycorine derivatives.
Evdokimov NM, Lamoral-Theys D, Mathieu V, Andolfi A, Frolova LV, Pelly SC, van Otterlo WA, Magedov IV, Kiss R, Evidente A, Kornienko A. Evdokimov NM, et al. Among authors: frolova lv. Bioorg Med Chem. 2011 Dec 1;19(23):7252-61. doi: 10.1016/j.bmc.2011.09.051. Epub 2011 Oct 2. Bioorg Med Chem. 2011. PMID: 22019045 Free PMC article.
Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.
Frolova LV, Magedov IV, Romero AE, Karki M, Otero I, Hayden K, Evdokimov NM, Banuls LM, Rastogi SK, Smith WR, Lu SL, Kiss R, Shuster CB, Hamel E, Betancourt T, Rogelj S, Kornienko A. Frolova LV, et al. J Med Chem. 2013 Sep 12;56(17):6886-900. doi: 10.1021/jm400711t. Epub 2013 Aug 23. J Med Chem. 2013. PMID: 23927793 Free PMC article.
Photoactivated 2,3-distyrylindoles kill multi-drug resistant bacteria.
Edwards L, Turner D, Champion C, Khandelwal M, Zingler K, Stone C, Rajapaksha RD, Yang J, Ranasinghe MI, Kornienko A, Frolova LV, Rogelj S. Edwards L, et al. Among authors: frolova lv. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1879-1886. doi: 10.1016/j.bmcl.2018.04.001. Epub 2018 Apr 3. Bioorg Med Chem Lett. 2018. PMID: 29673980 Free PMC article.
Reengineered epipodophyllotoxin.
Magedov IV, Evdokimov NM, Karki M, Peretti AS, Lima DT, Frolova LV, Reisenauer MR, Romero AE, Tongwa P, Fonari A, Altig J, Rogelj S, Antipin MY, Shuster CB, Kornienko A. Magedov IV, et al. Among authors: frolova lv. Chem Commun (Camb). 2012 Oct 28;48(84):10416-8. doi: 10.1039/c2cc35044k. Epub 2012 Sep 17. Chem Commun (Camb). 2012. PMID: 22986348 Free PMC article.
Synthetic and biological studies of tubulin targeting c2-substituted 7-deazahypoxanthines derived from marine alkaloid rigidins.
Scott R, Karki M, Reisenauer MR, Rodrigues R, Dasari R, Smith WR, Pelly SC, van Otterlo WAL, Shuster CB, Rogelj S, Magedov IV, Frolova LV, Kornienko A. Scott R, et al. Among authors: frolova lv. ChemMedChem. 2014 Jul;9(7):1428-1435. doi: 10.1002/cmdc.201300532. Epub 2014 Mar 18. ChemMedChem. 2014. PMID: 24644272 Free PMC article.
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