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Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing.
Gilmour BC, Gudmundsrud R, Frank J, Hov A, Lautrup S, Aman Y, Røsjø H, Brenner C, Ziegler M, Tysnes OB, Tzoulis C, Omland T, Søraas A, Holmøy T, Bergersen LH, Storm-Mathisen J, Nilsen H, Fang EF. Gilmour BC, et al. Among authors: brenner c. Mech Ageing Dev. 2020 Mar;186:111208. doi: 10.1016/j.mad.2020.111208. Epub 2020 Jan 15. Mech Ageing Dev. 2020. PMID: 31953124 Free article. Review.
Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.
Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R. Mitchell SJ, et al. Among authors: brenner c. Cell Metab. 2018 Mar 6;27(3):667-676.e4. doi: 10.1016/j.cmet.2018.02.001. Cell Metab. 2018. PMID: 29514072 Free PMC article.
NAD as a genotype-specific drug target.
Mei SC, Brenner C. Mei SC, et al. Among authors: brenner c. Chem Biol. 2013 Nov 21;20(11):1307-8. doi: 10.1016/j.chembiol.2013.11.001. Chem Biol. 2013. PMID: 24267273 Free PMC article.
Boosting NAD to spare hearing.
Brenner C. Brenner C. Cell Metab. 2014 Dec 2;20(6):926-7. doi: 10.1016/j.cmet.2014.11.015. Cell Metab. 2014. PMID: 25470539 Free article.
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.
Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, Tennant DA, Nightingale P, Wallis GA, Manolopoulos KN, Brenner C, Philp A, Lavery GG. Elhassan YS, et al. Among authors: brenner c. Cell Rep. 2019 Aug 13;28(7):1717-1728.e6. doi: 10.1016/j.celrep.2019.07.043. Cell Rep. 2019. PMID: 31412242 Free PMC article. Clinical Trial.
Modulation of the cardiac sodium channel NaV1.5 peak and late currents by NAD+ precursors.
Matasic DS, Yoon JY, McLendon JM, Mehdi H, Schmidt MS, Greiner AM, Quinones P, Morgan GM, Boudreau RL, Irani K, Brenner C, London B. Matasic DS, et al. Among authors: brenner c. J Mol Cell Cardiol. 2020 Apr;141:70-81. doi: 10.1016/j.yjmcc.2020.01.013. Epub 2020 Mar 21. J Mol Cell Cardiol. 2020. PMID: 32209328 Free PMC article.
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E. Covarrubias AJ, et al. Among authors: brenner c. Nat Metab. 2020 Nov;2(11):1265-1283. doi: 10.1038/s42255-020-00305-3. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199924 Free PMC article.
706 results