Abstract
Using high-throughput chemical and genetic screening, Matheny and colleagues (in this issue of Chemistry & Biology) identified STF-118804, an inhibitor of nicotinamide phosphoribosyltransferase, as a cell type-specific inhibitor of mixed-lineage leukemia with MLL chromosomal rearrangements. The approach was powerful, as is the potential for NAD as a specific cancer target.
Copyright © 2013 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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Benzamides / pharmacology*
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Cytokines / antagonists & inhibitors*
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Enzyme Inhibitors / pharmacology*
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Humans
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Male
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Nicotinamide Phosphoribosyltransferase / antagonists & inhibitors*
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Picolines / pharmacology*
Substances
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Antineoplastic Agents
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Benzamides
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Cytokines
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Enzyme Inhibitors
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Picolines
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STF-118804
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Nicotinamide Phosphoribosyltransferase
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nicotinamide phosphoribosyltransferase, human
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nicotinamide phosphoribosyltransferase, mouse