Boosting NAD to spare hearing

Charles Brenner

doi:10.1016/j.cmet.2014.11.015

Boosting NAD to spare hearing

Cell Metab. 2014 Dec 2;20(6):926-7. doi: 10.1016/j.cmet.2014.11.015.

Author

Charles Brenner¹

Affiliation

¹ Roy J. Carver Chair of Biochemistry and Professor of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address: charles-brenner@uiowa.edu.

PMID: 25470539
DOI: 10.1016/j.cmet.2014.11.015

Abstract

Ex vivo experiments have strangely shown that inhibition or stimulation of NAD metabolism can be neuroprotective. In this issue of Cell Metabolism, Brown et al. (2014) demonstrate that cochlear NAD is diminished by deafening noise but protected by nicotinamide riboside or WldS mutation. Hearing protection by nicotinamide riboside depends on Sirt3.

Publication types

Comment

MeSH terms

Animals
Female
Hearing Loss, Noise-Induced / prevention & control*
Male
NAD / therapeutic use*
Niacinamide / analogs & derivatives*
Sirtuin 3 / metabolism*

Substances

NAD
Niacinamide
Sirtuin 3