Jenny Legac - Search Results

Year	Number of Results
2017	1
2019	3
2020	5
2021	3
2022	5
2023	4
2024	3

1

Hitting drug-resistant malaria infection with triazole-linked flavonoid-chloroquine hybrid compounds.

Seghetti F, Belluti F, Rampa A, Gobbi S, Legac J, Parapini S, Basilico N, Bisi A. Seghetti F, et al. Among authors: legac j. Future Med Chem. 2022 Dec;14(24):1865-1880. doi: 10.4155/fmc-2022-0173. Epub 2022 Nov 22. Future Med Chem. 2022. PMID: 36622669

2

Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity.

Lopes EA, Mestre R, Fontinha D, Legac J, Pei JV, Sanches-Vaz M, Mori M, Lehane AM, Rosenthal PJ, Prudêncio M, Santos MMM. Lopes EA, et al. Among authors: legac j. Eur J Med Chem. 2022 Jun 5;236:114324. doi: 10.1016/j.ejmech.2022.114324. Epub 2022 Mar 28. Eur J Med Chem. 2022. PMID: 35390711

3

Quinoline-based heterocyclic hydrazones: Design, synthesis, anti-plasmodial assessment, and mechanistic insights.

Sharma B, Chowdhary S, Legac J, Rosenthal PJ, Kumar V. Sharma B, et al. Among authors: legac j. Chem Biol Drug Des. 2023 Apr;101(4):829-836. doi: 10.1111/cbdd.14185. Epub 2022 Dec 1. Chem Biol Drug Des. 2023. PMID: 36418231

4

Design, synthesis, crystal structure and anti-plasmodial evaluation of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives.

Pal K, Raza MK, Legac J, Ataur Rahman M, Manzoor S, Rosenthal PJ, Hoda N. Pal K, et al. Among authors: legac j. RSC Med Chem. 2021 May 18;12(6):970-981. doi: 10.1039/d1md00038a. eCollection 2021 Jun 23. RSC Med Chem. 2021. PMID: 34223162 Free PMC article.

5

Identification, Characterization, and Synthesis of Natural Parasitic Cysteine Protease Inhibitors: Pentacitidins Are More Potent Falcitidin Analogues.

Brinkmann S, Semmler S, Kersten C, Patras MA, Kurz M, Fuchs N, Hammerschmidt SJ, Legac J, Hammann PE, Vilcinskas A, Rosenthal PJ, Schirmeister T, Bauer A, Schäberle TF. Brinkmann S, et al. Among authors: legac j. ACS Chem Biol. 2022 Mar 18;17(3):576-589. doi: 10.1021/acschembio.1c00861. Epub 2022 Mar 9. ACS Chem Biol. 2022. PMID: 35262340

6

Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children.

Wallender E, Ali AM, Hughes E, Kakuru A, Jagannathan P, Muhindo MK, Opira B, Whalen M, Huang L, Duvalsaint M, Legac J, Kamya MR, Dorsey G, Aweeka F, Rosenthal PJ, Savic RM. Wallender E, et al. Among authors: legac j. Nat Commun. 2021 Nov 18;12(1):6714. doi: 10.1038/s41467-021-27051-8. Nat Commun. 2021. PMID: 34795281 Free PMC article. Clinical Trial.

7

A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies.

Rani A, Sharma A, Legac J, Rosenthal PJ, Singh P, Kumar V. Rani A, et al. Among authors: legac j. Bioorg Med Chem. 2021 Jun 1;39:116159. doi: 10.1016/j.bmc.2021.116159. Epub 2021 Apr 18. Bioorg Med Chem. 2021. PMID: 33895706

8

Amalgamating Isatin/Indole/Nitroimidazole with 7-chloroquinolines via azide-alkyne cycloaddition: Synthesis, anti-plasmodial, and cytotoxic evaluation.

Kumar S, Saini A, Legac J, Rosenthal PJ, Raj R, Kumar V. Kumar S, et al. Among authors: legac j. Chem Biol Drug Des. 2020 Dec;96(6):1355-1361. doi: 10.1111/cbdd.13738. Epub 2020 Jun 25. Chem Biol Drug Des. 2020. PMID: 32515142

9

Substituted 1,3-dioxoisoindoline-4-aminoquinolines coupled via amide linkers: Synthesis, antiplasmodial and cytotoxic evaluation.

Rani A, Legac J, Rosenthal PJ, Kumar V. Rani A, et al. Among authors: legac j. Bioorg Chem. 2019 Jul;88:102912. doi: 10.1016/j.bioorg.2019.04.006. Epub 2019 Apr 11. Bioorg Chem. 2019. PMID: 30991190

10

Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials.

Rani A, Kumar S, Legac J, Adeniyi AA, Awolade P, Singh P, Rosenthal PJ, Kumar V. Rani A, et al. Among authors: legac j. Future Med Chem. 2020 Feb;12(3):193-205. doi: 10.4155/fmc-2019-0260. Epub 2019 Dec 5. Future Med Chem. 2020. PMID: 31802710 Free PMC article.

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