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Small-molecule screening identifies modulators of aquaporin-2 trafficking.
Bogum J, Faust D, Zühlke K, Eichhorst J, Moutty MC, Furkert J, Eldahshan A, Neuenschwander M, von Kries JP, Wiesner B, Trimpert C, Deen PM, Valenti G, Rosenthal W, Klussmann E. Bogum J, et al. Among authors: von kries jp. J Am Soc Nephrol. 2013 Apr;24(5):744-58. doi: 10.1681/ASN.2012030295. Epub 2013 Apr 4. J Am Soc Nephrol. 2013. PMID: 23559583 Free PMC article.
Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes.
Christian F, Szaszák M, Friedl S, Drewianka S, Lorenz D, Goncalves A, Furkert J, Vargas C, Schmieder P, Götz F, Zühlke K, Moutty M, Göttert H, Joshi M, Reif B, Haase H, Morano I, Grossmann S, Klukovits A, Verli J, Gáspár R, Noack C, Bergmann M, Kass R, Hampel K, Kashin D, Genieser HG, Herberg FW, Willoughby D, Cooper DM, Baillie GS, Houslay MD, von Kries JP, Zimmermann B, Rosenthal W, Klussmann E. Christian F, et al. Among authors: von kries jp. J Biol Chem. 2011 Mar 18;286(11):9079-96. doi: 10.1074/jbc.M110.160614. Epub 2010 Dec 22. J Biol Chem. 2011. PMID: 21177871 Free PMC article.
Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions.
Schäfer G, Milić J, Eldahshan A, Götz F, Zühlke K, Schillinger C, Kreuchwig A, Elkins JM, Abdul Azeez KR, Oder A, Moutty MC, Masada N, Beerbaum M, Schlegel B, Niquet S, Schmieder P, Krause G, von Kries JP, Cooper DM, Knapp S, Rademann J, Rosenthal W, Klussmann E. Schäfer G, et al. Among authors: von kries jp. Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12187-91. doi: 10.1002/anie.201304686. Epub 2013 Sep 23. Angew Chem Int Ed Engl. 2013. PMID: 24115519 Free PMC article. No abstract available.
Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma.
Du J, Neuenschwander M, Yu Y, Däbritz JH, Neuendorff NR, Schleich K, Bittner A, Milanovic M, Beuster G, Radetzki S, Specker E, Reimann M, Rosenbauer F, Mathas S, Lohneis P, Hummel M, Dörken B, von Kries JP, Lee S, Schmitt CA. Du J, et al. Among authors: von kries jp. Blood. 2017 Jan 5;129(1):71-81. doi: 10.1182/blood-2016-02-700773. Epub 2016 Oct 12. Blood. 2017. PMID: 27733358 Free article.
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel C, Pifferi S, Picci C, Gök C, Hoffmann D, Bali KK, Lampe A, Lapatsina L, Fleischer R, Smith ES, Bégay V, Moroni M, Estebanez L, Kühnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Kuner R, Poulet JF, Schmoranzer J, Poole K, Lewin GR. Wetzel C, et al. Among authors: von kries jp. Nat Neurosci. 2017 Feb;20(2):209-218. doi: 10.1038/nn.4454. Epub 2016 Dec 12. Nat Neurosci. 2017. PMID: 27941788 Free article.
An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.
Schrade K, Tröger J, Eldahshan A, Zühlke K, Abdul Azeez KR, Elkins JM, Neuenschwander M, Oder A, Elkewedi M, Jaksch S, Andrae K, Li J, Fernandes J, Müller PM, Grunwald S, Marino SF, Vukićević T, Eichhorst J, Wiesner B, Weber M, Kapiloff M, Rocks O, Daumke O, Wieland T, Knapp S, von Kries JP, Klussmann E. Schrade K, et al. Among authors: von kries jp. PLoS One. 2018 Jan 26;13(1):e0191423. doi: 10.1371/journal.pone.0191423. eCollection 2018. PLoS One. 2018. PMID: 29373579 Free PMC article.
75 results