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Page 1
Metabolite releasing polymers control dendritic cell function by modulating their energy metabolism.
Mangal JL, Inamdar S, Yang Y, Dutta S, Wankhede M, Shi X, Gu H, Green M, Rege K, Curtis M, Acharya AP. Mangal JL, et al. J Mater Chem B. 2020 Jun 24;8(24):5195-5203. doi: 10.1039/d0tb00790k. J Mater Chem B. 2020. PMID: 32427266 Free PMC article.
Metabolites control immune cell functions, and delivery of these metabolites in a sustained manner may be able to modulate function of the immune cells. In this study, alpha-ketoglutarate (aKG) and diol based polymeric-microparticles (termed paKG MPs) were synthesized to p …
Metabolites control immune cell functions, and delivery of these metabolites in a sustained manner may be able to modulate function of the i …
Contact Dermatitis to Medications and Skin Products.
Nguyen HL, Yiannias JA. Nguyen HL, et al. Clin Rev Allergy Immunol. 2019 Feb;56(1):41-59. doi: 10.1007/s12016-018-8705-0. Clin Rev Allergy Immunol. 2019. PMID: 30145645 Review.
Finally, we examine the ingredients in the excipients of these products, such as the formaldehyde releasers (quaternium-15, 2-bromo-2-nitropropane-1,3 diol, diazolidinyl urea, imidazolidinyl urea, DMDM hydantoin), the non-formaldehyde releasers (isothiazolinones, parabens, …
Finally, we examine the ingredients in the excipients of these products, such as the formaldehyde releasers (quaternium-15, 2-bromo-2-nitrop …
Metabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study.
Bressler J, Yu B, Mosley TH, Knopman DS, Gottesman RF, Alonso A, Sharrett AR, Wruck LM, Boerwinkle E. Bressler J, et al. Transl Psychiatry. 2017 Jul 18;7(7):e1173. doi: 10.1038/tp.2017.118. Transl Psychiatry. 2017. PMID: 28934192 Free PMC article.
Two unnamed compounds and three sex steroid hormones were associated with an increased risk of dementia (all P<3.9 10(-4)). The association of 4-androstene-3beta, 17beta-diol disulfate 1 with dementia was replicated in European Americans. ...
Two unnamed compounds and three sex steroid hormones were associated with an increased risk of dementia (all P<3.9 10(-4)). The associati …
Trends in patch-test results and allergen changes in the standard series: a Mayo Clinic 5-year retrospective review (January 1, 2006, to December 31, 2010).
Wentworth AB, Yiannias JA, Keeling JH, Hall MR, Camilleri MJ, Drage LA, Torgerson RR, Fett DD, Prakash AV, Scalf LA, Allen EM, Johnson JS, Singh N, Nordberg Linehan DL, Killian JM, Davis MD. Wentworth AB, et al. J Am Acad Dermatol. 2014 Feb;70(2):269-75.e4. doi: 10.1016/j.jaad.2013.09.047. Epub 2013 Nov 20. J Am Acad Dermatol. 2014. PMID: 24268786
Rates were lower for 10 allergens: neomycin sulfate, 20%; gold sodium thiosulfate, 0.5%; hexahydro-1,3,5-tris(2-hydroxyethyl)triazine, 1%; disperse blue 124, 1%; disperse blue 106, 1%; diazolidinyl urea, 1%; hexylresorcinol, 0.25%; diazolidinyl urea, 1% aqueous; 2-bromo-2-nitropr …
Rates were lower for 10 allergens: neomycin sulfate, 20%; gold sodium thiosulfate, 0.5%; hexahydro-1,3,5-tris(2-hydroxyethyl)triazine, 1%; d …
Estrogen increases nitric-oxide production in human bronchial epithelium.
Townsend EA, Meuchel LW, Thompson MA, Pabelick CM, Prakash YS. Townsend EA, et al. J Pharmacol Exp Ther. 2011 Dec;339(3):815-24. doi: 10.1124/jpet.111.184416. Epub 2011 Sep 22. J Pharmacol Exp Ther. 2011. PMID: 21940647 Free PMC article.
Estrogen receptor (ER) isoform-specific agonists (R,R)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol (THC) (ERalpha) and diaryl-propionitrile (DPN) (ERbeta) stimulated NO production to comparable levels and at comparable rates, whereas the ER antagonist 7alpha,17beta-[9-[(4, …
Estrogen receptor (ER) isoform-specific agonists (R,R)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol (THC) (ERalpha) and diaryl-propion …
Reformulating polycaprolactone fumarate to eliminate toxic diethylene glycol: effects of polymeric branching and autoclave sterilization on material properties.
Runge MB, Wang H, Spinner RJ, Windebank AJ, Yaszemski MJ. Runge MB, et al. Acta Biomater. 2012 Jan;8(1):133-43. doi: 10.1016/j.actbio.2011.08.023. Epub 2011 Sep 1. Acta Biomater. 2012. PMID: 21911087 Free PMC article.
Polycaprolactone fumarate (PCLF) is a cross-linkable derivative of polycaprolactone diol that has been shown to be an effective nerve conduit material that supports regeneration across segmental nerve defects and has warranted future clinical trials. Degradation of PCLF (P …
Polycaprolactone fumarate (PCLF) is a cross-linkable derivative of polycaprolactone diol that has been shown to be an effective nerve …
Analysis of phenanthrene diol epoxide mercapturic acid detoxification products in human urine: relevance to molecular epidemiology studies of glutathione S-transferase polymorphisms.
Hecht SS, Villalta PW, Hochalter JB. Hecht SS, et al. Carcinogenesis. 2008 May;29(5):937-43. doi: 10.1093/carcin/bgn015. Epub 2008 May 13. Carcinogenesis. 2008. PMID: 18477646 Free PMC article.
We prepared standard mercapturic acids by reactions of syn- or anti-Phe-1,2-diol-3,4-epoxide and syn- or anti-Phe-3,4-diol-1,2-epoxide with N-acetylcysteine. Analysis of human urine conclusively demonstrated that the only detectable mercapturic acid of this type--N- …
We prepared standard mercapturic acids by reactions of syn- or anti-Phe-1,2-diol-3,4-epoxide and syn- or anti-Phe-3,4-diol-1,2 …
Longitudinal study of urinary phenanthrene metabolite ratios: effect of smoking on the diol epoxide pathway.
Hecht SS, Chen M, Yoder A, Jensen J, Hatsukami D, Le C, Carmella SG. Hecht SS, et al. Cancer Epidemiol Biomarkers Prev. 2005 Dec;14(12):2969-74. doi: 10.1158/1055-9965.EPI-05-0396. Cancer Epidemiol Biomarkers Prev. 2005. PMID: 16365018
In support of this proposal, we have developed methods for quantitation of r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT) and phenanthrols (HOPhe) in human urine. PheT is the end product of the diol epoxide metabolic activation pathway of PAH, whereas HOP …
In support of this proposal, we have developed methods for quantitation of r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT) …
Analysis of phenanthrols in human urine by gas chromatography-mass spectrometry: potential use in carcinogen metabolite phenotyping.
Carmella SG, Chen M, Yagi H, Jerina DM, Hecht SS. Carmella SG, et al. Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2167-74. Cancer Epidemiol Biomarkers Prev. 2004. PMID: 15598776
Previously, we reported a method for quantitation of r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (trans, anti-PheT) in human urine. trans, anti-PheT is the ultimate product of the diol epoxide metabolic activation pathway of phenanthrene. In this study, we ha …
Previously, we reported a method for quantitation of r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (trans, anti-PheT) in human u …
Steroid hormones and neurosteroids in normal and pathological aging of the nervous system.
Schumacher M, Weill-Engerer S, Liere P, Robert F, Franklin RJ, Garcia-Segura LM, Lambert JJ, Mayo W, Melcangi RC, Parducz A, Suter U, Carelli C, Baulieu EE, Akwa Y. Schumacher M, et al. Prog Neurobiol. 2003 Sep;71(1):3-29. doi: 10.1016/j.pneurobio.2003.09.004. Prog Neurobiol. 2003. PMID: 14611864 Review.
The conversion of dehydroepiandrosterone to Delta5-androstene-3beta,17beta-diol and to 7alpha-OH-dehydroepiandrosterone occurred in frontal cortex, hippocampus, amygdala, cerebellum and striatum of both Alzheimer's patients and controls. ...
The conversion of dehydroepiandrosterone to Delta5-androstene-3beta,17beta-diol and to 7alpha-OH-dehydroepiandrosterone occurred in f …
15 results