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Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition.
Wilson GA, Vuina K, Sava G, Huard C, Meneguello L, Coulombe-Huntington J, Bertomeu T, Maizels RJ, Lauring J, Kriston-Vizi J, Tyers M, Ali S, Bertoli C, de Bruin RAM. Wilson GA, et al. Among authors: de bruin ram. Mol Cell. 2023 Nov 16;83(22):4078-4092.e6. doi: 10.1016/j.molcel.2023.10.017. Epub 2023 Nov 16. Mol Cell. 2023. PMID: 37977119 Free article.
EZH2-Deficient T-cell Acute Lymphoblastic Leukemia Is Sensitized to CHK1 Inhibition through Enhanced Replication Stress.
León TE, Rapoz-D'Silva T, Bertoli C, Rahman S, Magnussen M, Philip B, Farah N, Richardson SE, Ahrabi S, Guerra-Assunção JA, Gupta R, Nacheva EP, Henderson S, Herrero J, Linch DC, de Bruin RAM, Mansour MR. León TE, et al. Among authors: de bruin ram. Cancer Discov. 2020 Jul;10(7):998-1017. doi: 10.1158/2159-8290.CD-19-0789. Epub 2020 Apr 29. Cancer Discov. 2020. PMID: 32349972 Free PMC article.
The proteasome controls ESCRT-III-mediated cell division in an archaeon.
Tarrason Risa G, Hurtig F, Bray S, Hafner AE, Harker-Kirschneck L, Faull P, Davis C, Papatziamou D, Mutavchiev DR, Fan C, Meneguello L, Arashiro Pulschen A, Dey G, Culley S, Kilkenny M, Souza DP, Pellegrini L, de Bruin RAM, Henriques R, Snijders AP, Šarić A, Lindås AC, Robinson NP, Baum B. Tarrason Risa G, et al. Among authors: de bruin ram. Science. 2020 Aug 7;369(6504):eaaz2532. doi: 10.1126/science.aaz2532. Science. 2020. PMID: 32764038 Free PMC article.
Cell cycle control in cancer.
Matthews HK, Bertoli C, de Bruin RAM. Matthews HK, et al. Among authors: de bruin ram. Nat Rev Mol Cell Biol. 2022 Jan;23(1):74-88. doi: 10.1038/s41580-021-00404-3. Epub 2021 Sep 10. Nat Rev Mol Cell Biol. 2022. PMID: 34508254 Review.
Vaccinia Virus Arrests and Shifts the Cell Cycle.
Martin CK, Samolej J, Olson AT, Bertoli C, Wiebe MS, de Bruin RAM, Mercer J. Martin CK, et al. Among authors: de bruin ram. Viruses. 2022 Feb 19;14(2):431. doi: 10.3390/v14020431. Viruses. 2022. PMID: 35216024 Free PMC article.
41 results