Control of S phase duration: a replication capacity model with E2F transcription at its heart

Cosetta Bertoli; Robertus A M de Bruin

doi:10.1080/23723556.2020.1839294

Control of S phase duration: a replication capacity model with E2F transcription at its heart

Mol Cell Oncol. 2021 Mar 8;8(2):1839294. doi: 10.1080/23723556.2020.1839294.

Authors

Cosetta Bertoli¹, Robertus A M de Bruin^{1

2}

Affiliations

¹ MRC Laboratory for Molecular Cell Biology, University College London, London, UK.
² UCL Cancer Institute, University College London, London, UK.

Abstract

DNA replication capacity, the maximal amount of DNA a cell can synthesize at any given time during S phase, is controlled by E2F-dependent transcription. Controlling replication capacity limits the replication rate and provides a robust mechanism to keep replication fork speed within an optimal range whilst ensuring timely completion of genome duplication.

Keywords: DNA replication; DNA replication capacity; E2F-dependent transcription; S phase; genome stability.

Grants and funding

20147/CRUK_/Cancer Research UK/United Kingdom