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Synthesis, 123I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures.
Hasnowo LA, Larkina MS, Plotnikov E, Bodenko V, Yuldasheva F, Stasyuk E, Petrov SA, Zyk NY, Machulkin AE, Vorozhtsov NI, Beloglazkina EK, Nenajdenko VG, Tolmachev V, Orlova A, Majouga AG, Yusubov MS. Hasnowo LA, et al. Among authors: zyk ny. Int J Mol Sci. 2023 Jul 30;24(15):12206. doi: 10.3390/ijms241512206. Int J Mol Sci. 2023. PMID: 37569582 Free PMC article.
Synthesis of Prostate-Specific Membrane Antigen-Targeted Bimodal Conjugates of Cytotoxic Agents and Antiandrogens and Their Comparative Assessment with Monoconjugates.
Zyk NY, Garanina AS, Plotnikova EA, Ber AP, Nimenko EA, Dashkova NS, Uspenskaia AA, Shafikov RR, Skvortsov DA, Petrov SA, Pankratov AA, Zyk NV, Majouga AG, Beloglazkina EK, Machulkin AE. Zyk NY, et al. Int J Mol Sci. 2023 Jul 11;24(14):11327. doi: 10.3390/ijms241411327. Int J Mol Sci. 2023. PMID: 37511087 Free PMC article.
Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with 177Lu.
Machulkin AE, Petrov SA, Bodenko V, Larkina MS, Plotnikov E, Yuldasheva F, Tretyakova M, Bezverkhniaia E, Zyk NY, Stasyuk E, Zelchan R, Majouga AG, Tolmachev V, Orlova A, Beloglazkina EK, Yusubov MS. Machulkin AE, et al. Among authors: zyk ny. ACS Pharmacol Transl Sci. 2024 May 1;7(5):1457-1473. doi: 10.1021/acsptsci.4c00070. eCollection 2024 May 10. ACS Pharmacol Transl Sci. 2024. PMID: 38751647
PSMA-targeted small-molecule docetaxel conjugate: Synthesis and preclinical evaluation.
Machulkin AE, Uspenskaya AA, Zyk NY, Nimenko EA, Ber AP, Petrov SA, Shafikov RR, Skvortsov DA, Smirnova GB, Borisova YA, Pokrovsky VS, Kolmogorov VS, Vaneev AN, Ivanenkov YA, Khudyakov AD, Kovalev SV, Erofeev AS, Gorelkin PV, Beloglazkina EK, Zyk NV, Khazanova ES, Majouga AG. Machulkin AE, et al. Among authors: zyk ny. Eur J Med Chem. 2022 Jan 5;227:113936. doi: 10.1016/j.ejmech.2021.113936. Epub 2021 Oct 23. Eur J Med Chem. 2022. PMID: 34717125
Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen.
Petrov SA, Machulkin AE, Uspenskaya AA, Zyk NY, Nimenko EA, Garanina AS, Petrov RA, Polshakov VI, Grishin YK, Roznyatovsky VA, Zyk NV, Majouga AG, Beloglazkina EK. Petrov SA, et al. Among authors: zyk ny. Molecules. 2020 Dec 8;25(24):5784. doi: 10.3390/molecules25245784. Molecules. 2020. PMID: 33302417 Free PMC article.