Abstract
This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53- Mouse double minute 2 homolog (MDM2) protein-protein interaction. The main focus is placed on synthetic approaches to such molecules, their cytotoxicity, and MDM2 binding characteristics.
Keywords:
anticancer drugs; cytotoxicity; p53–MDM2 inhibitors.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Biological Products / chemistry
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Biological Products / pharmacology
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Humans
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Protein Interaction Domains and Motifs / drug effects*
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Proto-Oncogene Proteins c-mdm2 / metabolism*
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Small Molecule Libraries / chemistry*
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Small Molecule Libraries / pharmacology*
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Tumor Suppressor Protein p53 / metabolism*
Substances
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Antineoplastic Agents
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Biological Products
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Small Molecule Libraries
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TP53 protein, human
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Tumor Suppressor Protein p53
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MDM2 protein, human
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Proto-Oncogene Proteins c-mdm2