Recent Small-Molecule Inhibitors of the p53-MDM2 Protein-Protein Interaction

Molecules. 2020 Mar 7;25(5):1211. doi: 10.3390/molecules25051211.

Abstract

This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53- Mouse double minute 2 homolog (MDM2) protein-protein interaction. The main focus is placed on synthetic approaches to such molecules, their cytotoxicity, and MDM2 binding characteristics.

Keywords: anticancer drugs; cytotoxicity; p53–MDM2 inhibitors.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Biological Products / chemistry
  • Biological Products / pharmacology
  • Humans
  • Protein Interaction Domains and Motifs / drug effects*
  • Proto-Oncogene Proteins c-mdm2 / metabolism*
  • Small Molecule Libraries / chemistry*
  • Small Molecule Libraries / pharmacology*
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Antineoplastic Agents
  • Biological Products
  • Small Molecule Libraries
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2