Zhang T - Search Results

1

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance.

Zhang T, Qu R, Chan S, Lai M, Tong L, Feng F, Chen H, Song T, Song P, Bai G, Liu Y, Wang Y, Li Y, Su Y, Shen Y, Sun Y, Chen Y, Geng M, Ding K, Ding J, Xie H. Zhang T, et al. Mol Cancer. 2020 May 13;19(1):90. doi: 10.1186/s12943-020-01202-9. Mol Cancer. 2020. PMID: 32404161 Free PMC article.

2

Correction to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance.

Zhang T, Qu R, Chan S, Lai M, Tong L, Feng F, Chen H, Song T, Song P, Bai G, Liu Y, Wang Y, Li Y, Su Y, Shen Y, Sun Y, Chen Y, Geng M, Ding K, Ding J, Xie H. Zhang T, et al. Mol Cancer. 2021 Aug 17;20(1):102. doi: 10.1186/s12943-021-01391-x. Mol Cancer. 2021. PMID: 34404402 Free PMC article. No abstract available.

3

Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma.

Chen Y, Bai G, Ning Y, Cai S, Zhang T, Song P, Zhou J, Duan W, Ding J, Xie H, Zhang H. Chen Y, et al. Among authors: zhang t, zhang h. Eur J Med Chem. 2020 Mar 15;190:112092. doi: 10.1016/j.ejmech.2020.112092. Epub 2020 Jan 25. Eur J Med Chem. 2020. PMID: 32014679

4

Design and synthesis of selective degraders of EGFR^L858R/T790M mutant.

Zhang X, Xu F, Tong L, Zhang T, Xie H, Lu X, Ren X, Ding K. Zhang X, et al. Among authors: zhang t. Eur J Med Chem. 2020 Apr 15;192:112199. doi: 10.1016/j.ejmech.2020.112199. Epub 2020 Mar 5. Eur J Med Chem. 2020. PMID: 32171162

5

Design, Synthesis, and Biological Evaluation of IRAK4-Targeting PROTACs.

Chen Y, Ning Y, Bai G, Tong L, Zhang T, Zhou J, Zhang H, Xie H, Ding J, Duan W. Chen Y, et al. Among authors: zhang t, zhang h. ACS Med Chem Lett. 2020 Dec 10;12(1):82-87. doi: 10.1021/acsmedchemlett.0c00474. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488968 Free PMC article.

6

Optimization of Brigatinib as New Wild-Type Sparing Inhibitors of EGFR^T790M/C797S Mutants.

Li S, Zhang T, Zhu SJ, Lei C, Lai M, Peng L, Tong L, Pang Z, Lu X, Ding J, Ren X, Yun CH, Xie H, Ding K. Li S, et al. Among authors: zhang t. ACS Med Chem Lett. 2022 Jan 7;13(2):196-202. doi: 10.1021/acsmedchemlett.1c00555. eCollection 2022 Feb 10. ACS Med Chem Lett. 2022. PMID: 35178175 Free PMC article.

7

A Novel Method to Synthesize 4-Aryl-1H-1,2,3-Triazoles and its Antihepatoma Activity.

Li X, He Y, Hai L, Zhang T, Wu Y. Li X, et al. Among authors: zhang t. Anticancer Agents Med Chem. 2016;16(12):1622-1627. doi: 10.2174/1871520616666151123095646. Anticancer Agents Med Chem. 2016. PMID: 26592747

8

D-ring modified novel isosteviol derivatives: design, synthesis and cytotoxic activity evaluation.

Zhang T, Lu LH, Liu H, Wang JW, Wang RX, Zhang YX, Tao JC. Zhang T, et al. Among authors: zhang yx. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5827-32. doi: 10.1016/j.bmcl.2012.07.083. Epub 2012 Jul 31. Bioorg Med Chem Lett. 2012. PMID: 22901386

9

Antitumor and toxicity study of mitochondria-targeted triptolide derivatives using triphenylphosphine (TPP⁺) as a carrier.

Song H, Xing W, Shi X, Zhang T, Lou H, Fan P. Song H, et al. Among authors: zhang t. Bioorg Med Chem. 2021 Nov 15;50:116466. doi: 10.1016/j.bmc.2021.116466. Epub 2021 Oct 13. Bioorg Med Chem. 2021. PMID: 34700239

10

Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer Mechanisms.

Ye Y, Zhang T, Yuan H, Li D, Lou H, Fan P. Ye Y, et al. Among authors: zhang t. J Med Chem. 2017 Jul 27;60(14):6353-6363. doi: 10.1021/acs.jmedchem.7b00679. Epub 2017 Jul 18. J Med Chem. 2017. PMID: 28671831

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