Abstract
A series of polyhydric, amino alcohol and tricyclic derivatives were facilely synthesized by D-ring modification of isosteviol. These compounds were screened for their cytotoxic activities against four human tumor cell lines in vitro. Among them, the 15-α-aminomethyl-16-β-hydroxyl isosteviol 23 exhibits significant cytotoxicity superior to the positive control (cisplatin) against EC9706, PC-3 and HCT-116 cell lines.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Diterpenes, Kaurane / chemical synthesis
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Diterpenes, Kaurane / chemistry
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Diterpenes, Kaurane / pharmacology*
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Dose-Response Relationship, Drug
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Drug Design*
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Drug Screening Assays, Antitumor
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HCT116 Cells
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Humans
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Molecular Structure
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Diterpenes, Kaurane
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isosteviol