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High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects.
Tong H, Huang J, Xiao Q, He B, Dong X, Liu Y, Yang X, Han D, Wang Z, Wang X, Ying W, Zhang R, Wei Y, Xu C, Zhou Y, Li Y, Cai M, Wang Q, Xue M, Li G, Fang K, Zhang H, Yang H. Tong H, et al. Among authors: zhang r, zhang h. Nat Biotechnol. 2023 Jan;41(1):108-119. doi: 10.1038/s41587-022-01419-7. Epub 2022 Aug 11. Nat Biotechnol. 2023. PMID: 35953673
Perfecting Targeting in CRISPR.
Zhang H, Li T, Sun Y, Yang H. Zhang H, et al. Annu Rev Genet. 2021 Nov 23;55:453-477. doi: 10.1146/annurev-genet-071719-030438. Epub 2021 Sep 16. Annu Rev Genet. 2021. PMID: 34530641 Review.
Development of miniature base editors using engineered IscB nickase.
Han D, Xiao Q, Wang Y, Zhang H, Dong X, Li G, Kong X, Wang S, Song J, Zhang W, Zhou J, Bi L, Yuan Y, Shi L, Zhong N, Yang H, Zhou Y. Han D, et al. Among authors: zhang w, zhang h. Nat Methods. 2023 Jul;20(7):1029-1036. doi: 10.1038/s41592-023-01898-9. Epub 2023 May 25. Nat Methods. 2023. PMID: 37231266
An engineered xCas12i with high activity, high specificity, and broad PAM range.
Zhang H, Kong X, Xue M, Hu J, Wang Z, Wei Y, Wang H, Zhou J, Zhang W, Xu M, Shen X, Yin F, Ai Z, Huang G, Xia J, Song X, Li H, Yuan Y, Li J, Zhong N, Zhang M, Zhou Y, Yang H. Zhang H, et al. Among authors: zhang m, zhang w. Protein Cell. 2023 Jun 28;14(7):538-543. doi: 10.1093/procel/pwac052. Protein Cell. 2023. PMID: 37378659 Free PMC article. No abstract available.
In vivo treatment of tyrosinaemia with hypercompact Cas12f1.
Guo R, Li Z, Li G, Zhang H, Zhang C, Huo X, Zhang X, Yang X, Yang R, Liu Y, Sun X, Liu X, Yang H, Zhou Y, Xu C. Guo R, et al. Among authors: zhang c, zhang h, zhang x. Cell Discov. 2023 Jul 18;9(1):73. doi: 10.1038/s41421-023-00554-y. Cell Discov. 2023. PMID: 37460535 Free PMC article. No abstract available.
Engineering a transposon-associated TnpB-ωRNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model.
Li Z, Guo R, Sun X, Li G, Shao Z, Huo X, Yang R, Liu X, Cao X, Zhang H, Zhang W, Zhang X, Ma S, Zhang M, Liu Y, Yao Y, Shi J, Yang H, Hu C, Zhou Y, Xu C. Li Z, et al. Among authors: zhang m, zhang w, zhang h, zhang x. Nat Commun. 2024 Jan 27;15(1):831. doi: 10.1038/s41467-024-45197-z. Nat Commun. 2024. PMID: 38280857 Free PMC article.
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