Zettl H - Search Results

1

Nonsteroidal anti-inflammatory drugs: a critical review on current concepts applied to reduce gastrointestinal toxicity.

Abdel-Tawab M, Zettl H, Schubert-Zsilavecz M. Abdel-Tawab M, et al. Among authors: zettl h. Curr Med Chem. 2009;16(16):2042-63. doi: 10.2174/092986709788682209. Curr Med Chem. 2009. PMID: 19519380 Review.

2

Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Zettl H, Greiner C, Wurglics M, Schubert-Zsilavecz M, Werz O. Koeberle A, et al. Among authors: zettl h. J Med Chem. 2008 Dec 25;51(24):8068-76. doi: 10.1021/jm801085s. J Med Chem. 2008. PMID: 19053751

3

Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol.

Rörsch F, Wobst I, Zettl H, Schubert-Zsilavecz M, Grösch S, Geisslinger G, Schneider G, Proschak E. Rörsch F, et al. Among authors: zettl h. J Med Chem. 2010 Jan 28;53(2):911-5. doi: 10.1021/jm9012505. J Med Chem. 2010. PMID: 20025212

4

A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold.

Hieke M, Greiner C, Thieme TM, Schubert-Zsilavecz M, Werz O, Zettl H. Hieke M, et al. Among authors: zettl h. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1329-33. doi: 10.1016/j.bmcl.2011.01.049. Epub 2011 Jan 18. Bioorg Med Chem Lett. 2011. PMID: 21310608

5

SAR studies of acidic dual γ-secretase/PPARγ modulators.

Hieke M, Ness J, Steri R, Greiner C, Werz O, Schubert-Zsilavecz M, Weggen S, Zettl H. Hieke M, et al. Among authors: zettl h. Bioorg Med Chem. 2011 Sep 15;19(18):5372-82. doi: 10.1016/j.bmc.2011.08.003. Epub 2011 Aug 6. Bioorg Med Chem. 2011. PMID: 21873070

6

Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists.

Zettl H, Steri R, Lämmerhofer M, Schubert-Zsilavecz M. Zettl H, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4421-6. doi: 10.1016/j.bmcl.2009.05.057. Epub 2009 May 18. Bioorg Med Chem Lett. 2009. PMID: 19556125

7

Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.

Hieke M, Ness J, Steri R, Dittrich M, Greiner C, Werz O, Baumann K, Schubert-Zsilavecz M, Weggen S, Zettl H. Hieke M, et al. Among authors: zettl h. J Med Chem. 2010 Jun 24;53(12):4691-700. doi: 10.1021/jm1003073. J Med Chem. 2010. PMID: 20503989

8

Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.

Greiner C, Zettl H, Koeberle A, Pergola C, Northoff H, Schubert-Zsilavecz M, Werz O. Greiner C, et al. Among authors: zettl h. Bioorg Med Chem. 2011 Jun 1;19(11):3394-401. doi: 10.1016/j.bmc.2011.04.034. Epub 2011 Apr 22. Bioorg Med Chem. 2011. PMID: 21570310

9

[From cocaine to innovative antiemetics. The medicinal chemistry of 5-ht3 receptor antagonists].

Zettl H, Schubert-Zsilavecz M, Siebert CD. Zettl H, et al. Pharm Unserer Zeit. 2007;36(5):354-61. doi: 10.1002/pauz.200700231. Pharm Unserer Zeit. 2007. PMID: 17722162 Review. German. No abstract available.

10

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.

Koeberle A, Rossi A, Zettl H, Pergola C, Dehm F, Bauer J, Greiner C, Reckel S, Hoernig C, Northoff H, Bernhard F, Dötsch V, Sautebin L, Schubert-Zsilavecz M, Werz O. Koeberle A, et al. Among authors: zettl h. J Pharmacol Exp Ther. 2010 Mar;332(3):840-8. doi: 10.1124/jpet.109.160663. Epub 2009 Nov 24. J Pharmacol Exp Ther. 2010. PMID: 19934399

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