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PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.
Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, Hong S, Shi Y, Santana M, Kueth C, Macklin-Isquierdo S, Perry S, Duhaime S, Maios C, Chang J, Perez J, Couto A, Lai J, Li Y, Alworth SV, Hendricks E, Wang Y, Zlokovic BV, Dickman DK, Parker JA, Zarnescu DC, Gao FB, Ichida JK. Hung ST, et al. Among authors: zarnescu dc. Cell. 2023 Feb 16;186(4):786-802.e28. doi: 10.1016/j.cell.2023.01.005. Epub 2023 Feb 7. Cell. 2023. PMID: 36754049 Free PMC article.
Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS.
Coyne AN, Lorenzini I, Chou CC, Torvund M, Rogers RS, Starr A, Zaepfel BL, Levy J, Johannesmeyer J, Schwartz JC, Nishimune H, Zinsmaier K, Rossoll W, Sattler R, Zarnescu DC. Coyne AN, et al. Among authors: zarnescu dc. Cell Rep. 2017 Oct 3;21(1):110-125. doi: 10.1016/j.celrep.2017.09.028. Cell Rep. 2017. PMID: 28978466 Free PMC article.
The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease.
Bakkar N, Starr A, Rabichow BE, Lorenzini I, McEachin ZT, Kraft R, Chaung M, Macklin-Isquierdo S, Wingfield T, Carhart B, Zahler N, Chang WH, Bassell GJ, Betourne A, Boulis N, Alworth SV, Ichida JK, August PR, Zarnescu DC, Sattler R, Bowser R. Bakkar N, et al. Among authors: zarnescu dc. Neurobiol Dis. 2021 Feb;149:105228. doi: 10.1016/j.nbd.2020.105228. Epub 2020 Dec 24. Neurobiol Dis. 2021. PMID: 33359139 Free PMC article.
Ferrying wingless across the synaptic cleft.
Zarnescu DC, Zinsmaier KE. Zarnescu DC, et al. Cell. 2009 Oct 16;139(2):229-31. doi: 10.1016/j.cell.2009.09.032. Cell. 2009. PMID: 19837027 Free article.
TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6.
Lehmkuhl EM, Loganathan S, Alsop E, Blythe AD, Kovalik T, Mortimore NP, Barrameda D, Kueth C, Eck RJ, Siddegowda BB, Joardar A, Ball H, Macias ME, Bowser R, Van Keuren-Jensen K, Zarnescu DC. Lehmkuhl EM, et al. Among authors: zarnescu dc. Acta Neuropathol Commun. 2021 Mar 24;9(1):52. doi: 10.1186/s40478-021-01148-z. Acta Neuropathol Commun. 2021. PMID: 33762006 Free PMC article.
Fragile X protein functions with lgl and the par complex in flies and mice.
Zarnescu DC, Jin P, Betschinger J, Nakamoto M, Wang Y, Dockendorff TC, Feng Y, Jongens TA, Sisson JC, Knoblich JA, Warren ST, Moses K. Zarnescu DC, et al. Dev Cell. 2005 Jan;8(1):43-52. doi: 10.1016/j.devcel.2004.10.020. Dev Cell. 2005. PMID: 15621528 Free article.
51 results