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Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva.
Williams E, Bagarova J, Kerr G, Xia DD, Place ES, Dey D, Shen Y, Bocobo GA, Mohedas AH, Huang X, Sanderson PE, Lee A, Zheng W, Economides AN, Smith JC, Yu PB, Bullock AN. Williams E, et al. Among authors: yu pb. JCI Insight. 2021 Apr 22;6(8):e95042. doi: 10.1172/jci.insight.95042. JCI Insight. 2021. PMID: 33705358 Free PMC article.
Development of an ALK2-biased BMP type I receptor kinase inhibitor.
Mohedas AH, Xing X, Armstrong KA, Bullock AN, Cuny GD, Yu PB. Mohedas AH, et al. Among authors: yu pb. ACS Chem Biol. 2013;8(6):1291-302. doi: 10.1021/cb300655w. Epub 2013 Apr 30. ACS Chem Biol. 2013. PMID: 23547776 Free PMC article.
Constitutively active ALK2 receptor mutants require type II receptor cooperation.
Bagarova J, Vonner AJ, Armstrong KA, Börgermann J, Lai CS, Deng DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y, Yu PB. Bagarova J, et al. Among authors: yu pb. Mol Cell Biol. 2013 Jun;33(12):2413-24. doi: 10.1128/MCB.01595-12. Epub 2013 Apr 9. Mol Cell Biol. 2013. PMID: 23572558 Free PMC article.
A new class of small molecule inhibitor of BMP signaling.
Sanvitale CE, Kerr G, Chaikuad A, Ramel MC, Mohedas AH, Reichert S, Wang Y, Triffitt JT, Cuny GD, Yu PB, Hill CS, Bullock AN. Sanvitale CE, et al. Among authors: yu pb. PLoS One. 2013 Apr 30;8(4):e62721. doi: 10.1371/journal.pone.0062721. Print 2013. PLoS One. 2013. PMID: 23646137 Free PMC article.
ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.
Hatsell SJ, Idone V, Wolken DM, Huang L, Kim HJ, Wang L, Wen X, Nannuru KC, Jimenez J, Xie L, Das N, Makhoul G, Chernomorsky R, D'Ambrosio D, Corpina RA, Schoenherr CJ, Feeley K, Yu PB, Yancopoulos GD, Murphy AJ, Economides AN. Hatsell SJ, et al. Among authors: yu pb. Sci Transl Med. 2015 Sep 2;7(303):303ra137. doi: 10.1126/scitranslmed.aac4358. Sci Transl Med. 2015. PMID: 26333933 Free PMC article.
Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.
Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB. Dey D, et al. Among authors: yu pb. Sci Transl Med. 2016 Nov 23;8(366):366ra163. doi: 10.1126/scitranslmed.aaf1090. Sci Transl Med. 2016. PMID: 27881824 Free PMC article.
The traumatic bone: trauma-induced heterotopic ossification.
Dey D, Wheatley BM, Cholok D, Agarwal S, Yu PB, Levi B, Davis TA. Dey D, et al. Among authors: yu pb. Transl Res. 2017 Aug;186:95-111. doi: 10.1016/j.trsl.2017.06.004. Epub 2017 Jun 15. Transl Res. 2017. PMID: 28668522 Free PMC article. Review.
128 results