Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation

Haematologica. 2015 Feb;100(2):e68-71. doi: 10.3324/haematol.2014.111484. Epub 2014 Oct 17.
No abstract available

Keywords: BMP inhibitor; anemia of inflammation; hepcidin.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Anemia / drug therapy*
  • Anemia / etiology*
  • Animals
  • Biological Availability
  • Blotting, Western
  • Bone Morphogenetic Protein Receptors, Type I / antagonists & inhibitors*
  • Bone Morphogenetic Proteins / genetics
  • Bone Morphogenetic Proteins / metabolism
  • Cells, Cultured
  • Female
  • Inflammation / chemically induced
  • Inflammation / complications*
  • Irritants / toxicity
  • Mice
  • Mice, Inbred C57BL
  • Pyrazoles / administration & dosage
  • Pyrazoles / pharmacokinetics
  • Pyrazoles / pharmacology*
  • Pyrimidines / administration & dosage
  • Pyrimidines / pharmacokinetics
  • Pyrimidines / pharmacology*
  • RNA, Messenger / genetics
  • Real-Time Polymerase Chain Reaction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tissue Distribution
  • Turpentine / toxicity

Substances

  • Bone Morphogenetic Proteins
  • Irritants
  • LDN 193189
  • Pyrazoles
  • Pyrimidines
  • RNA, Messenger
  • Bone Morphogenetic Protein Receptors, Type I
  • Turpentine