You Q - Search Results

1

Targeting m⁶A binding protein YTHDFs for cancer therapy.

Zhang W, Wu T, Zhang Y, Kang W, Du C, You Q, Chen X, Jiang Z. Zhang W, et al. Among authors: you q. Bioorg Med Chem. 2023 Jul 15;90:117373. doi: 10.1016/j.bmc.2023.117373. Epub 2023 Jun 12. Bioorg Med Chem. 2023. PMID: 37329678 Review.

2

Synthesis and evaluation of novel aza-caged Garcinia xanthones.

Zhang X, Li X, Sun H, Jiang Z, Tao L, Gao Y, Guo Q, You Q. Zhang X, et al. Among authors: you q. Org Biomol Chem. 2012 Apr 28;10(16):3288-99. doi: 10.1039/c2ob07088j. Epub 2012 Mar 12. Org Biomol Chem. 2012. PMID: 22407464

3

Novel IKKβ inhibitors discovery based on the co-crystal structure by using binding-conformation-based and ligand-based method.

Huang JJ, Wu XW, Jia JM, Guo XK, Xue X, Jiang ZY, Zhang SL, Zhang XJ, Sun HP, You QD. Huang JJ, et al. Eur J Med Chem. 2013 May;63:269-78. doi: 10.1016/j.ejmech.2013.01.045. Epub 2013 Feb 17. Eur J Med Chem. 2013. PMID: 23501112

4

Synthesis and bioevaluation of a series of α-pyrone derivatives as potent activators of Nrf2/ARE pathway (part I).

Xi MY, Sun ZY, Sun HP, Jia JM, Jiang ZY, Tao L, Ye M, Yang X, Wang YJ, Xue X, Huang JJ, Gao Y, Guo XK, Zhang SL, Yang YR, Guo QL, Hu R, You QD. Xi MY, et al. Eur J Med Chem. 2013 Aug;66:364-71. doi: 10.1016/j.ejmech.2013.06.007. Epub 2013 Jun 14. Eur J Med Chem. 2013. PMID: 23820128

5

Discovery and design of tricyclic scaffolds as protein kinase CK2 (CK2) inhibitors through a combination of shape-based virtual screening and structure-based molecular modification.

Sun H, Xu X, Wu X, Zhang X, Liu F, Jia J, Guo X, Huang J, Jiang Z, Feng T, Chu H, Zhou Y, Zhang S, Liu Z, You Q. Sun H, et al. Among authors: you q. J Chem Inf Model. 2013 Aug 26;53(8):2093-102. doi: 10.1021/ci400114f. Epub 2013 Aug 12. J Chem Inf Model. 2013. PMID: 23937544

6

3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.

Xi MY, Jia JM, Sun HP, Sun ZY, Jiang JW, Wang YJ, Zhang MY, Zhu JF, Xu LL, Jiang ZY, Xue X, Ye M, Yang X, Gao Y, Tao L, Guo XK, Xu XL, Guo QL, Zhang XJ, Hu R, You QD. Xi MY, et al. J Med Chem. 2013 Oct 24;56(20):7925-38. doi: 10.1021/jm400944k. Epub 2013 Oct 9. J Med Chem. 2013. PMID: 24053646

7

Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation.

Jiang ZY, Chu HX, Xi MY, Yang TT, Jia JM, Huang JJ, Guo XK, Zhang XJ, You QD, Sun HP. Jiang ZY, et al. PLoS One. 2013 Sep 16;8(9):e75076. doi: 10.1371/journal.pone.0075076. eCollection 2013. PLoS One. 2013. PMID: 24066166 Free PMC article.

8

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors.

Guo X, Yang Q, Xu J, Zhang L, Chu H, Yu P, Zhu Y, Wei J, Chen W, Zhang Y, Zhang X, Sun H, Tang Y, You Q. Guo X, et al. Among authors: you q. Bioorg Med Chem. 2013 Nov 1;21(21):6466-76. doi: 10.1016/j.bmc.2013.08.041. Epub 2013 Aug 31. Bioorg Med Chem. 2013. PMID: 24071446

9

Discovery of novel CK2 leads by cross-docking based virtual screening.

Sun H, Wu X, Xu X, Jiang Z, Liu Z, You Q. Sun H, et al. Among authors: you q. Med Chem. 2014;10(6):628-39. doi: 10.2174/1573406409666131128143601. Med Chem. 2014. PMID: 24286395

10

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.

Jiang ZY, Lu MC, Xu LL, Yang TT, Xi MY, Xu XL, Guo XK, Zhang XJ, You QD, Sun HP. Jiang ZY, et al. J Med Chem. 2014 Mar 27;57(6):2736-45. doi: 10.1021/jm5000529. Epub 2014 Feb 21. J Med Chem. 2014. PMID: 24512214

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