Targeting m6A binding protein YTHDFs for cancer therapy

Bioorg Med Chem. 2023 Jul 15:90:117373. doi: 10.1016/j.bmc.2023.117373. Epub 2023 Jun 12.

Abstract

N6-methyladenosine (m6A) is the most common mRNA modification in mammalians. The function and dynamic regulation of m6A depends on the "writer", "readers" and "erasers". YT521-B homology domain family (YTHDF) is a class of m6A binding proteins, including YTHDF1, YTHDF2 and YTHDF3. In recent years, the modification of m6A and the molecular mechanism of YTHDFs have been further understood. Growing evidence has shown that YTHDFs participate in multifarious bioprocesses, particularly tumorigenesis. In this review, we summarized the structural characteristics of YTHDFs, the regulation of mRNA by YTHDFs, the role of YTHDF proteins in human cancers and inhibition of YTHDFs.

Keywords: Cancer therapy; YTHDF proteins; YTHDFs inhibition; m(6)A modification; m(6)A readers.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / chemistry
  • Animals
  • Carrier Proteins*
  • Humans
  • Mammals / metabolism
  • Neoplasms* / drug therapy
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Transcription Factors / metabolism

Substances

  • Carrier Proteins
  • RNA-Binding Proteins
  • RNA, Messenger
  • Transcription Factors
  • Adenosine