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The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer.
Amara CS, Kami Reddy KR, Yuntao Y, Chan YS, Piyarathna DWB, Dobrolecki LE, Shih DJH, Shi Z, Xu J, Huang S, Ellis MJ, Apolo AB, Ballester LY, Gao J, Hansel DE, Lotan Y, Hodges HC, Lerner SP, Creighton CJ, Sreekumar A, Zheng WJ, Msaouel P, Kavuri SM, Putluri N. Amara CS, et al. Among authors: xu j. Nat Commun. 2024 Feb 14;15(1):1373. doi: 10.1038/s41467-024-45132-2. Nat Commun. 2024. PMID: 38355560 Free PMC article.
S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy.
Li J, Shu X, Xu J, Su SM, Chan UI, Mo L, Liu J, Zhang X, Adhav R, Chen Q, Wang Y, An T, Zhang X, Lyu X, Li X, Lei JH, Miao K, Sun H, Xing F, Zhang A, Deng C, Xu X. Li J, et al. Among authors: xu x, xu j. Nat Commun. 2022 Mar 18;13(1):1481. doi: 10.1038/s41467-022-29151-5. Nat Commun. 2022. PMID: 35304461 Free PMC article.
Activation of FGFR2 Signaling Suppresses BRCA1 and Drives Triple-Negative Mammary Tumorigenesis That is Sensitive to Immunotherapy.
Lei JH, Lee MH, Miao K, Huang Z, Yao Z, Zhang A, Xu J, Zhao M, Huang Z, Zhang X, Chen S, Jiaying NG, Feng Y, Xing F, Chen P, Sun H, Chen Q, Xiang T, Chen L, Xu X, Deng CX. Lei JH, et al. Among authors: xu x, xu j. Adv Sci (Weinh). 2021 Nov;8(21):e2100974. doi: 10.1002/advs.202100974. Epub 2021 Sep 13. Adv Sci (Weinh). 2021. PMID: 34514747 Free PMC article.
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