Wittinghofer A - Search Results

1

Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes.

Rosnizeck IC, Graf T, Spoerner M, Tränkle J, Filchtinski D, Herrmann C, Gremer L, Vetter IR, Wittinghofer A, König B, Kalbitzer HR. Rosnizeck IC, et al. Among authors: wittinghofer a. Angew Chem Int Ed Engl. 2010 May 17;49(22):3830-3. doi: 10.1002/anie.200907002. Angew Chem Int Ed Engl. 2010. PMID: 20401883 No abstract available.

2

Dynamic properties of the Ras switch I region and its importance for binding to effectors.

Spoerner M, Herrmann C, Vetter IR, Kalbitzer HR, Wittinghofer A. Spoerner M, et al. Among authors: wittinghofer a. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):4944-9. doi: 10.1073/pnas.081441398. Proc Natl Acad Sci U S A. 2001. PMID: 11320243 Free PMC article.

3

Conformational states of Ras complexed with the GTP analogue GppNHp or GppCH2p: implications for the interaction with effector proteins.

Spoerner M, Nuehs A, Ganser P, Herrmann C, Wittinghofer A, Kalbitzer HR. Spoerner M, et al. Among authors: wittinghofer a. Biochemistry. 2005 Feb 15;44(6):2225-36. doi: 10.1021/bi0488000. Biochemistry. 2005. PMID: 15697248

4

Structure-function relationships of the G domain, a canonical switch motif.

Wittinghofer A, Vetter IR. Wittinghofer A, et al. Annu Rev Biochem. 2011;80:943-71. doi: 10.1146/annurev-biochem-062708-134043. Annu Rev Biochem. 2011. PMID: 21675921 Review.

5

Perturbation of the conformational equilibria in Ras by selective mutations as studied by 31P NMR spectroscopy.

Spoerner M, Wittinghofer A, Kalbitzer HR. Spoerner M, et al. Among authors: wittinghofer a. FEBS Lett. 2004 Dec 17;578(3):305-10. doi: 10.1016/j.febslet.2004.11.020. FEBS Lett. 2004. PMID: 15589837 Free article.

6

The structure of the TrmE GTP-binding protein and its implications for tRNA modification.

Scrima A, Vetter IR, Armengod ME, Wittinghofer A. Scrima A, et al. Among authors: wittinghofer a. EMBO J. 2005 Jan 12;24(1):23-33. doi: 10.1038/sj.emboj.7600507. Epub 2004 Dec 16. EMBO J. 2005. PMID: 15616586 Free PMC article.

7

Synthesis of the Rheb and K-Ras4B GTPases.

Chen YX, Koch S, Uhlenbrock K, Weise K, Das D, Gremer L, Brunsveld L, Wittinghofer A, Winter R, Triola G, Waldmann H. Chen YX, et al. Among authors: wittinghofer a. Angew Chem Int Ed Engl. 2010 Aug 16;49(35):6090-5. doi: 10.1002/anie.201001884. Angew Chem Int Ed Engl. 2010. PMID: 20652921 No abstract available.

8

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase.

Herrmann C, Martin GA, Wittinghofer A. Herrmann C, et al. Among authors: wittinghofer a. J Biol Chem. 1995 Feb 17;270(7):2901-5. doi: 10.1074/jbc.270.7.2901. J Biol Chem. 1995. PMID: 7852367 Free article.

9

Structural and biochemical analysis of Ras-effector signaling via RalGDS.

Vetter IR, Linnemann T, Wohlgemuth S, Geyer M, Kalbitzer HR, Herrmann C, Wittinghofer A. Vetter IR, et al. Among authors: wittinghofer a. FEBS Lett. 1999 May 21;451(2):175-80. doi: 10.1016/s0014-5793(99)00555-4. FEBS Lett. 1999. PMID: 10371160 Free article.

10

The guanine nucleotide-binding switch in three dimensions.

Vetter IR, Wittinghofer A. Vetter IR, et al. Among authors: wittinghofer a. Science. 2001 Nov 9;294(5545):1299-304. doi: 10.1126/science.1062023. Science. 2001. PMID: 11701921 Review.

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