White PW - Search Results

1

Structure-thermodynamics-relationships of hepatitis C viral NS3 protease inhibitors.

Wypych RM, LaPlante SR, White PW, Martin SF. Wypych RM, et al. Among authors: white pw. Eur J Med Chem. 2020 Apr 15;192:112195. doi: 10.1016/j.ejmech.2020.112195. Epub 2020 Feb 28. Eur J Med Chem. 2020. PMID: 32151833

2

Discovery of a potent and selective noncovalent linear inhibitor of the hepatitis C virus NS3 protease (BI 201335).

Llinàs-Brunet M, Bailey MD, Goudreau N, Bhardwaj PK, Bordeleau J, Bös M, Bousquet Y, Cordingley MG, Duan J, Forgione P, Garneau M, Ghiro E, Gorys V, Goulet S, Halmos T, Kawai SH, Naud J, Poupart MA, White PW. Llinàs-Brunet M, et al. Among authors: white pw. J Med Chem. 2010 Sep 9;53(17):6466-76. doi: 10.1021/jm100690x. J Med Chem. 2010. PMID: 20715823

3

Discovery of hepatitis C virus NS3-4A protease inhibitors with improved barrier to resistance and favorable liver distribution.

Moreau B, O'Meara JA, Bordeleau J, Garneau M, Godbout C, Gorys V, Leblanc M, Villemure E, White PW, Llinàs-Brunet M. Moreau B, et al. Among authors: white pw. J Med Chem. 2014 Mar 13;57(5):1770-6. doi: 10.1021/jm400121t. Epub 2013 Mar 28. J Med Chem. 2014. PMID: 23506530

4

Synthesis and optimization of a novel series of HCV NS3 protease inhibitors: 4-arylproline analogs.

Bilodeau F, Bailey MD, Bhardwaj PK, Bordeleau J, Forgione P, Garneau M, Ghiro E, Gorys V, Halmos T, Jolicoeur ES, Leblanc M, Lemke CT, Naud J, O'Meara J, White PW, Llinàs-Brunet M. Bilodeau F, et al. Among authors: white pw. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4267-71. doi: 10.1016/j.bmcl.2013.03.043. Epub 2013 Mar 19. Bioorg Med Chem Lett. 2013. PMID: 23735741

5

Peptide backbone replacement of hepatitis C virus NS3 serine protease C-terminal cleavage product analogs: discovery of potent succinamide inhibitors.

Bailey MD, Bordeleau J, Garneau M, Leblanc M, Lemke CT, O'Meara J, White PW, Llinàs-Brunet M. Bailey MD, et al. Among authors: white pw. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4447-52. doi: 10.1016/j.bmcl.2013.05.045. Epub 2013 May 23. Bioorg Med Chem Lett. 2013. PMID: 23773863

6

Blunting the Swiss army knife of hepatitis C virus: inhibitors of NS3/4A protease.

White PW, Llinas-Brunet M, Bös M. White PW, et al. Prog Med Chem. 2006;44:65-107. doi: 10.1016/S0079-6468(05)44402-1. Prog Med Chem. 2006. PMID: 16697895 Review. No abstract available.

7

Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.

Lemke CT, Goudreau N, Zhao S, Hucke O, Thibeault D, Llinàs-Brunet M, White PW. Lemke CT, et al. Among authors: white pw. J Biol Chem. 2011 Apr 1;286(13):11434-43. doi: 10.1074/jbc.M110.211417. Epub 2011 Jan 26. J Biol Chem. 2011. PMID: 21270126 Free PMC article.

8

Molecular mechanism by which a potent hepatitis C virus NS3-NS4A protease inhibitor overcomes emergence of resistance.

O'Meara JA, Lemke CT, Godbout C, Kukolj G, Lagacé L, Moreau B, Thibeault D, White PW, Llinàs-Brunet M. O'Meara JA, et al. Among authors: white pw. J Biol Chem. 2013 Feb 22;288(8):5673-81. doi: 10.1074/jbc.M112.439455. Epub 2012 Dec 27. J Biol Chem. 2013. PMID: 23271737 Free PMC article.

9

Use of the fused NS4A peptide-NS3 protease domain to study the importance of the helicase domain for protease inhibitor binding to hepatitis C virus NS3-NS4A.

Thibeault D, Massariol MJ, Zhao S, Welchner E, Goudreau N, Gingras R, Llinàs-Brunet M, White PW. Thibeault D, et al. Among authors: white pw. Biochemistry. 2009 Feb 3;48(4):744-53. doi: 10.1021/bi801931e. Biochemistry. 2009. PMID: 19119853

10

Discovery of small-molecule inhibitors of the ATPase activity of human papillomavirus E1 helicase.

Faucher AM, White PW, Brochu C, Grand-Maître C, Rancourt J, Fazal G. Faucher AM, et al. Among authors: white pw. J Med Chem. 2004 Jan 1;47(1):18-21. doi: 10.1021/jm034206x. J Med Chem. 2004. PMID: 14695816

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