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Homodimerization attenuates the anti-inflammatory activity of interleukin-37.
Ellisdon AM, Nold-Petry CA, D'Andrea L, Cho SX, Lao JC, Rudloff I, Ngo D, Lo CY, Soares da Costa TP, Perugini MA, Conroy PJ, Whisstock JC, Nold MF. Ellisdon AM, et al. Among authors: whisstock jc. Sci Immunol. 2017 Feb 10;2(8):eaaj1548. doi: 10.1126/sciimmunol.aaj1548. Sci Immunol. 2017. PMID: 28783685
A common fold mediates vertebrate defense and bacterial attack.
Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani JA, Bird PI, Dunstone MA, Whisstock JC. Rosado CJ, et al. Among authors: whisstock jc. Science. 2007 Sep 14;317(5844):1548-51. doi: 10.1126/science.1144706. Epub 2007 Aug 23. Science. 2007. PMID: 17717151
Reconciling the structural attributes of avian antibodies.
Conroy PJ, Law RH, Gilgunn S, Hearty S, Caradoc-Davies TT, Lloyd G, O'Kennedy RJ, Whisstock JC. Conroy PJ, et al. Among authors: whisstock jc. J Biol Chem. 2014 May 30;289(22):15384-92. doi: 10.1074/jbc.M114.562470. Epub 2014 Apr 15. J Biol Chem. 2014. PMID: 24737329 Free PMC article.
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.
Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF. Nold-Petry CA, et al. Among authors: whisstock jc. Nat Immunol. 2015 Apr;16(4):354-65. doi: 10.1038/ni.3103. Epub 2015 Mar 2. Nat Immunol. 2015. PMID: 25729923
The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM. Lucato CM, et al. Among authors: whisstock jc. J Biol Chem. 2015 Aug 21;290(34):20827-20840. doi: 10.1074/jbc.M115.660456. Epub 2015 Jun 24. J Biol Chem. 2015. PMID: 26112412 Free PMC article.
268 results