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TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation.
Ho JSY, Mok BW, Campisi L, Jordan T, Yildiz S, Parameswaran S, Wayman JA, Gaudreault NN, Meekins DA, Indran SV, Morozov I, Trujillo JD, Fstkchyan YS, Rathnasinghe R, Zhu Z, Zheng S, Zhao N, White K, Ray-Jones H, Malysheva V, Thiecke MJ, Lau SY, Liu H, Zhang AJ, Lee AC, Liu WC, Jangra S, Escalera A, Aydillo T, Melo BS, Guccione E, Sebra R, Shum E, Bakker J, Kaufman DA, Moreira AL, Carossino M, Balasuriya UBR, Byun M, Albrecht RA, Schotsaert M, Garcia-Sastre A, Chanda SK, Miraldi ER, Jeyasekharan AD, TenOever BR, Spivakov M, Weirauch MT, Heinz S, Chen H, Benner C, Richt JA, Marazzi I. Ho JSY, et al. Among authors: weirauch mt. Cell. 2021 May 13;184(10):2618-2632.e17. doi: 10.1016/j.cell.2021.03.051. Epub 2021 Mar 30. Cell. 2021. PMID: 33836156 Free PMC article.
The genetic etiology of eosinophilic esophagitis.
Kottyan LC, Parameswaran S, Weirauch MT, Rothenberg ME, Martin LJ. Kottyan LC, et al. Among authors: weirauch mt. J Allergy Clin Immunol. 2020 Jan;145(1):9-15. doi: 10.1016/j.jaci.2019.11.013. J Allergy Clin Immunol. 2020. PMID: 31910986 Free PMC article. Review.
Human Virus Transcriptional Regulators.
Liu X, Hong T, Parameswaran S, Ernst K, Marazzi I, Weirauch MT, Fuxman Bass JI. Liu X, et al. Among authors: weirauch mt. Cell. 2020 Jul 9;182(1):24-37. doi: 10.1016/j.cell.2020.06.023. Cell. 2020. PMID: 32649876 Free PMC article. Review.
Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.
Yuin Ho JS, Wing-Yee Mok B, Campisi L, Jordan T, Yildiz S, Parameswaran S, Wayman JA, Gaudreault NN, Meekins DA, Indran SV, Morozov I, Trujillo JD, Fstkchyan YS, Rathnasinghe R, Zhu Z, Zheng S, Zhao N, White K, Ray-Jones H, Malysheva V, Thiecke MJ, Lau SY, Liu H, Junxia Zhang A, Chak-Yiu Lee A, Liu WC, Aydillo T, Salom Melo B, Guccione E, Sebra R, Shum E, Bakker J, Kaufman DA, Moreira AL, Carossino M, Balasuriya UBR, Byun M, Miraldi ER, Albrecht RA, Schotsaert M, Garcia-Sastre A, Chanda SK, Jeyasekharan AD, TenOever BR, Spivakov M, Weirauch MT, Heinz S, Chen H, Benner C, Richt JA, Marazzi I. Yuin Ho JS, et al. Among authors: weirauch mt. bioRxiv [Preprint]. 2020 Dec 1:2020.12.01.404483. doi: 10.1101/2020.12.01.404483. bioRxiv. 2020. PMID: 33299999 Free PMC article. Updated. Preprint.
Deciphering cis-regulatory grammar with deep learning.
Miraldi ER, Chen X, Weirauch MT. Miraldi ER, et al. Among authors: weirauch mt. Nat Genet. 2021 Mar;53(3):266-268. doi: 10.1038/s41588-021-00814-1. Nat Genet. 2021. PMID: 33686263 No abstract available.
Global discovery of lupus genetic risk variant allelic enhancer activity.
Lu X, Chen X, Forney C, Donmez O, Miller D, Parameswaran S, Hong T, Huang Y, Pujato M, Cazares T, Miraldi ER, Ray JP, de Boer CG, Harley JB, Weirauch MT, Kottyan LC. Lu X, et al. Among authors: weirauch mt. Nat Commun. 2021 Mar 12;12(1):1611. doi: 10.1038/s41467-021-21854-5. Nat Commun. 2021. PMID: 33712590 Free PMC article.
IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility.
Song R, Gao Y, Dozmorov I, Malladi V, Saha I, McDaniel MM, Parameswaran S, Liang C, Arana C, Zhang B, Wakeland B, Zhou J, Weirauch MT, Kottyan LC, Wakeland EK, Pasare C. Song R, et al. Among authors: weirauch mt. Cell Rep. 2021 Mar 23;34(12):108891. doi: 10.1016/j.celrep.2021.108891. Cell Rep. 2021. PMID: 33761354 Free PMC article.
Runx Transcription Factors in T Cells-What Is Beyond Thymic Development?
Korinfskaya S, Parameswaran S, Weirauch MT, Barski A. Korinfskaya S, et al. Among authors: weirauch mt. Front Immunol. 2021 Aug 6;12:701924. doi: 10.3389/fimmu.2021.701924. eCollection 2021. Front Immunol. 2021. PMID: 34421907 Free PMC article. Review.
182 results