Human Virus Transcriptional Regulators

Xing Liu; Ted Hong; Sreeja Parameswaran; Kevin Ernst; Ivan Marazzi; Matthew T Weirauch; Juan I Fuxman Bass

doi:10.1016/j.cell.2020.06.023

Human Virus Transcriptional Regulators

Cell. 2020 Jul 9;182(1):24-37. doi: 10.1016/j.cell.2020.06.023.

Authors

Xing Liu¹, Ted Hong², Sreeja Parameswaran³, Kevin Ernst³, Ivan Marazzi⁴, Matthew T Weirauch⁵, Juan I Fuxman Bass⁶

Affiliations

¹ Biology Department, Boston University, Boston, MA 02215, USA.
² Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pharmacology and Systems Physiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA.
³ Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
⁴ Department of Microbiology, Mount Sinai Hospital Icahn School of Medicine, New York, NY 10029-5674, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
⁵ Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address: matthew.weirauch@cchmc.org.
⁶ Biology Department, Boston University, Boston, MA 02215, USA; Bioinformatics Program, Boston University, Boston, MA 02215, USA. Electronic address: fuxman@bu.edu.

Abstract

Viral genomes encode transcriptional regulators that alter the expression of viral and host genes. Despite an emerging role in human diseases, a thorough annotation of human viral transcriptional regulators (vTRs) is currently lacking, limiting our understanding of their molecular features and functions. Here, we provide a comprehensive catalog of 419 vTRs belonging to 20 different virus families. Using this catalog, we characterize shared and unique cellular genes, proteins, and pathways targeted by particular vTRs and discuss the role of vTRs in human disease pathogenesis. Our study provides a unique and valuable resource for the fields of virology, genomics, and human disease genetics.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Epigenesis, Genetic
Humans
Models, Biological
Protein Interaction Maps
Transcription, Genetic*
Viral Proteins / chemistry
Viral Proteins / genetics
Viral Proteins / metabolism*

Substances

Viral Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding