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Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-β Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice.
Sun B, Rouzbehani OMT, Kramer RJ, Ghosh R, Perelli RM, Atkins S, Fatahian AN, Davis K, Szulik MW, Goodman MA, Hathaway MA, Chi E, Word TA, Tunuguntla H, Denfield SW, Wehrens XHT, Whitehead KJ, Abdelnasser HY, Warren JS, Wu M, Franklin S, Boudina S, Landstrom AP. Sun B, et al. Among authors: warren js. Circ Heart Fail. 2023 Dec;16(12):e010351. doi: 10.1161/CIRCHEARTFAILURE.122.010351. Epub 2023 Dec 19. Circ Heart Fail. 2023. PMID: 38113297
Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart.
Warren JS, Tracy CM, Miller MR, Makaju A, Szulik MW, Oka SI, Yuzyuk TN, Cox JE, Kumar A, Lozier BK, Wang L, Llana JG, Sabry AD, Cawley KM, Barton DW, Han YH, Boudina S, Fiehn O, Tucker HO, Zaitsev AV, Franklin S. Warren JS, et al. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7871-E7880. doi: 10.1073/pnas.1800680115. Epub 2018 Jul 30. Proc Natl Acad Sci U S A. 2018. PMID: 30061404 Free PMC article.
The lncRNA Caren antagonizes heart failure by inactivating DNA damage response and activating mitochondrial biogenesis.
Sato M, Kadomatsu T, Miyata K, Warren JS, Tian Z, Zhu S, Horiguchi H, Makaju A, Bakhtina A, Morinaga J, Sugizaki T, Hirashima K, Yoshinobu K, Imasaka M, Araki M, Komohara Y, Wakayama T, Nakagawa S, Franklin S, Node K, Araki K, Oike Y. Sato M, et al. Among authors: warren js. Nat Commun. 2021 May 5;12(1):2529. doi: 10.1038/s41467-021-22735-7. Nat Commun. 2021. PMID: 33953175 Free PMC article.
Recruitment of RNA Polymerase II to Metabolic Gene Promoters Is Inhibited in the Failing Heart Possibly Through PGC-1α (Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α) Dysregulation.
Bhat S, Chin A, Shirakabe A, Ikeda Y, Ikeda S, Zhai P, Hsu CP, Sayed D, Abdellatif M, Byun J, Schesing K, Tang F, Tian Y, Babu G, Ralda G, Warren JS, Cho J, Sadoshima J, Oka SI. Bhat S, et al. Among authors: warren js. Circ Heart Fail. 2019 Mar;12(3):e005529. doi: 10.1161/CIRCHEARTFAILURE.118.005529. Circ Heart Fail. 2019. PMID: 30798619 Free PMC article.
Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy.
Oka SI, Byun J, Huang CY, Imai N, Ralda G, Zhai P, Xu X, Kashyap S, Warren JS, Alan Maschek J, Tippetts TS, Tong M, Venkatesh S, Ikeda Y, Mizushima W, Kashihara T, Sadoshima J. Oka SI, et al. Among authors: warren js. Circ Res. 2021 Jun 25;129(1):114-130. doi: 10.1161/CIRCRESAHA.120.317943. Epub 2021 Apr 30. Circ Res. 2021. PMID: 33928788 Free PMC article.
Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1.
Oka SI, Sabry AD, Horiuchi AK, Cawley KM, O'Very SA, Zaitsev MA, Shankar TS, Byun J, Mukai R, Xu X, Torres NS, Kumar A, Yazawa M, Ling J, Taleb I, Saijoh Y, Drakos SG, Sadoshima J, Warren JS. Oka SI, et al. Among authors: warren js. PLoS One. 2020 Jun 23;15(6):e0234913. doi: 10.1371/journal.pone.0234913. eCollection 2020. PLoS One. 2020. PMID: 32574189 Free PMC article.
Multiple Levels of PGC-1α Dysregulation in Heart Failure.
Oka SI, Sabry AD, Cawley KM, Warren JS. Oka SI, et al. Among authors: warren js. Front Cardiovasc Med. 2020 Jan 30;7:2. doi: 10.3389/fcvm.2020.00002. eCollection 2020. Front Cardiovasc Med. 2020. PMID: 32083094 Free PMC article. Review.
140 results