Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy

Circ Res. 2021 Jun 25;129(1):114-130. doi: 10.1161/CIRCRESAHA.120.317943. Epub 2021 Apr 30.

Shin-Ichi Oka¹, Jaemin Byun¹, Chun-Yang Huang^{1

2

3}, Nobushige Imai¹, Guersom Ralda¹, Peiyong Zhai¹, Xiaoyong Xu^{1

4}, Sanchita Kashyap¹, Junco S Warren⁵, John Alan Maschek^{6

7}, Trevor S Tippetts⁸, Mingming Tong¹, Sundararajan Venkatesh^{9

8}, Yoshiyuki Ikeda¹, Wataru Mizushima¹, Toshihide Kashihara¹, Junichi Sadoshima¹

¹ Department of Cell Biology and Molecular Medicine (S.-i.O., J.B., C.-y.H., N.I., G.R., P.Z., X.X., S.K., M.T., Y.I., W.M., T.K., J.S.), Rutgers New Jersey Medical School, Newark.
² Division of Cardiovascular Surgery, Department of Surgery, Taipei Veterans General Hospital, Taiwan (C.-y.H.).
³ Institute of Clinical Medicine, School of Medicine National Yang-Ming University, Taipei, Taiwan (C.-y.H.).
⁴ Department of Cardiology, Ningbo Medical Center Lihuili Hospital, Zhejiang, China (X.X.).
⁵ Nora Eccles Harrison Cardiovascular Research and Training Institute (J.S.W.), University of Utah, Salt Lake City.
⁶ Metabolomics, Proteomics, and Mass Spectrometry Cores (J.A.M.), University of Utah, Salt Lake City.
⁷ Department of Nutrition and Integrative Physiology (J.A.M.), University of Utah, Salt Lake City.
⁸ Department of Nutrition and Integrative Physiology and the Diabetes and Metabolism Research Center (T.S.T., S.V.), University of Utah, Salt Lake City.
⁹ Department of Microbiology, Biochemistry, and Molecular Genetics (S.V.), Rutgers New Jersey Medical School, Newark.

Abstract

[Figure: see text].

Keywords: apoptosis; diabetic cardiomyopathies; fatty acids; fibrosis; oxidative stress.