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Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL.
Zhang J, Hu Y, Yang J, Li W, Zhang M, Wang Q, Zhang L, Wei G, Tian Y, Zhao K, Chen A, Tan B, Cui J, Li D, Li Y, Qi Y, Wang D, Wu Y, Li D, Du B, Liu M, Huang H. Zhang J, et al. Among authors: wang d, wang q. Nature. 2022 Sep;609(7926):369-374. doi: 10.1038/s41586-022-05140-y. Epub 2022 Aug 31. Nature. 2022. PMID: 36045296 Free PMC article. Clinical Trial.
CAR T cells for brain tumors: Lessons learned and road ahead.
Akhavan D, Alizadeh D, Wang D, Weist MR, Shepphird JK, Brown CE. Akhavan D, et al. Among authors: wang d. Immunol Rev. 2019 Jul;290(1):60-84. doi: 10.1111/imr.12773. Immunol Rev. 2019. PMID: 31355493 Free PMC article. Review.
Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma.
Wang D, Starr R, Chang WC, Aguilar B, Alizadeh D, Wright SL, Yang X, Brito A, Sarkissian A, Ostberg JR, Li L, Shi Y, Gutova M, Aboody K, Badie B, Forman SJ, Barish ME, Brown CE. Wang D, et al. Sci Transl Med. 2020 Mar 4;12(533):eaaw2672. doi: 10.1126/scitranslmed.aaw2672. Sci Transl Med. 2020. PMID: 32132216 Free PMC article.
Genetically modified CD7-targeting allogeneic CAR-T cell therapy with enhanced efficacy for relapsed/refractory CD7-positive hematological malignancies: a phase I clinical study.
Hu Y, Zhou Y, Zhang M, Zhao H, Wei G, Ge W, Cui Q, Mu Q, Chen G, Han L, Guo T, Cui J, Jiang X, Zheng X, Yu S, Li X, Zhang X, Chen M, Li X, Gao M, Wang K, Zu C, Zhang H, He X, Wang Y, Wang D, Ren J, Huang H. Hu Y, et al. Among authors: wang k, wang y, wang d. Cell Res. 2022 Nov;32(11):995-1007. doi: 10.1038/s41422-022-00721-y. Epub 2022 Sep 23. Cell Res. 2022. PMID: 36151216 Free PMC article. Clinical Trial.
Potency monitoring of CAR T cells.
Wang D, Yang X, Xella A, Stern LA, Brown CE. Wang D, et al. Methods Cell Biol. 2023;173:173-189. doi: 10.1016/bs.mcb.2022.07.010. Epub 2022 Sep 6. Methods Cell Biol. 2023. PMID: 36653083
GPRC5D CAR T cells (OriCAR-017) in patients with relapsed or refractory multiple myeloma (POLARIS): a first-in-human, single-centre, single-arm, phase 1 trial.
Zhang M, Wei G, Zhou L, Zhou J, Chen S, Zhang W, Wang D, Luo X, Cui J, Huang S, Fu S, Zhou X, Tang Y, Ding X, Kuang J, He XP, Hu Y, Huang H. Zhang M, et al. Among authors: wang d. Lancet Haematol. 2023 Feb;10(2):e107-e116. doi: 10.1016/S2352-3026(22)00372-6. Lancet Haematol. 2023. PMID: 36725117 Clinical Trial.
Safety and efficacy of CRISPR-based non-viral PD1 locus specifically integrated anti-CD19 CAR-T cells in patients with relapsed or refractory Non-Hodgkin's lymphoma: a first-in-human phase I study.
Hu Y, Zu C, Zhang M, Wei G, Li W, Fu S, Hong R, Zhou L, Wu W, Cui J, Wang D, Du B, Liu M, Zhang J, Huang H. Hu Y, et al. Among authors: wang d. EClinicalMedicine. 2023 May 18;60:102010. doi: 10.1016/j.eclinm.2023.102010. eCollection 2023 Jun. EClinicalMedicine. 2023. PMID: 37251628 Free PMC article.
Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation.
Si X, Shao M, Teng X, Huang Y, Meng Y, Wu L, Wei J, Liu L, Gu T, Song J, Jing R, Zhai X, Guo X, Kong D, Wang X, Cai B, Shen Y, Zhang Z, Wang D, Hu Y, Qian P, Xiao G, Huang H. Si X, et al. Among authors: wang x, wang d. Cell Metab. 2024 Jan 2;36(1):176-192.e10. doi: 10.1016/j.cmet.2023.12.010. Cell Metab. 2024. PMID: 38171332
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