Wähälä K - Search Results

1

Novel Sulfonanilide Inhibitors of SHIP2 Enhance Glucose Uptake into Cultured Myotubes.

Berg MEA, Naams JB, Hautala LC, Tolvanen TA, Ahonen JP, Lehtonen S, Wähälä K. Berg MEA, et al. Among authors: wahala k. ACS Omega. 2020 Jan 14;5(3):1430-1438. doi: 10.1021/acsomega.9b02944. eCollection 2020 Jan 28. ACS Omega. 2020. PMID: 32010815 Free PMC article.

2

Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity.

Polianskyte-Prause Z, Tolvanen TA, Lindfors S, Dumont V, Van M, Wang H, Dash SN, Berg M, Naams JB, Hautala LC, Nisen H, Mirtti T, Groop PH, Wähälä K, Tienari J, Lehtonen S. Polianskyte-Prause Z, et al. Among authors: wahala k. FASEB J. 2019 Feb;33(2):2858-2869. doi: 10.1096/fj.201800529RR. Epub 2018 Oct 15. FASEB J. 2019. PMID: 30321069 Free PMC article.

3

Pharmacophore modelling of 17beta-HSD1 enzyme based on active inhibitors and enzyme structure.

Karkola S, Alho-Richmond S, Wahala K. Karkola S, et al. Among authors: wahala k. Mol Cell Endocrinol. 2009 Mar 25;301(1-2):225-8. doi: 10.1016/j.mce.2008.08.030. Epub 2008 Sep 6. Mol Cell Endocrinol. 2009. PMID: 18822344

4

Synthesis of enterolactone and enterodiol precursors as potential inhibitors of human estrogen synthetase (aromatase).

Mäkelä TH, Wähälä KT, Hase TA. Mäkelä TH, et al. Among authors: wahala kt. Steroids. 2000 Aug;65(8):437-41. doi: 10.1016/s0039-128x(00)00104-5. Steroids. 2000. PMID: 10936614

5

Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.

Round P, Das S, Wu TS, Wähälä K, Van Petegem F, Hammond GL. Round P, et al. Among authors: wahala k. J Biol Chem. 2020 Jan 31;295(5):1202-1211. doi: 10.1074/jbc.RA119.011051. Epub 2019 Dec 18. J Biol Chem. 2020. PMID: 31852737 Free PMC article.

6

A three-dimensional model of CYP19 aromatase for structure-based drug design.

Karkola S, Höltje HD, Wähälä K. Karkola S, et al. Among authors: wahala k. J Steroid Biochem Mol Biol. 2007 Jun-Jul;105(1-5):63-70. doi: 10.1016/j.jsbmb.2006.11.023. Epub 2007 May 17. J Steroid Biochem Mol Biol. 2007. PMID: 17583493

7

A 3D QSAR model of 17beta-HSD1 inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core applying molecular dynamics simulations and ligand-protein docking.

Karkola S, Lilienkampf A, Wähälä K. Karkola S, et al. Among authors: wahala k. ChemMedChem. 2008 Mar;3(3):461-72. doi: 10.1002/cmdc.200700271. ChemMedChem. 2008. PMID: 18224704

8

The binding of lignans, flavonoids and coumestrol to CYP450 aromatase: a molecular modelling study.

Karkola S, Wähälä K. Karkola S, et al. Among authors: wahala k. Mol Cell Endocrinol. 2009 Mar 25;301(1-2):235-44. doi: 10.1016/j.mce.2008.10.003. Epub 2008 Oct 19. Mol Cell Endocrinol. 2009. PMID: 19000737

9

Synthesis and biological evaluation of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core.

Lilienkampf A, Karkola S, Alho-Richmond S, Koskimies P, Johansson N, Huhtinen K, Vihko K, Wähälä K. Lilienkampf A, et al. Among authors: wahala k. J Med Chem. 2009 Nov 12;52(21):6660-71. doi: 10.1021/jm900928k. J Med Chem. 2009. PMID: 19824648

10

Active site analysis of 17beta-hydroxysteroid dehydrogenase type 1 enzyme complexes with SPROUT.

Alho-Richmond S, Lilienkampf A, Wähälä K. Alho-Richmond S, et al. Among authors: wahala k. Mol Cell Endocrinol. 2006 Mar 27;248(1-2):208-13. doi: 10.1016/j.mce.2005.12.004. Epub 2006 Jan 10. Mol Cell Endocrinol. 2006. PMID: 16412556

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